This application requests renewal of the Hebrew Rehabilitation Center for Aged (HRCA)/Harvard Research Nursing Home (RNH) program project. Over the past 15 this program has become a unique, multi-disciplinary collaboration of investigators from 4 academic hospitals and 3 universities in the Boston area that share the common goal of conduct high-quality clinical research focused on prevalent, disabling, previously neglected syndromes that threaten the independence and quality of life of elderly people. During the next five years we plan to move from studies of pathophysiology of clinical syndromes in the nursing home to the development of new diagnostic tools and interventions to prevent disability and improve the well-being of elderly people in all long-term care settings. The participating institutions are HRCA, Brigham and Women's Hospital, Massachusetts General Hospital, Boston University, Harvard Medical School, and the University of Massachusetts School of Nursing. These projects represent the continuation of work by principal investigators who have been in the RNH program since its inception. In addition, we have recruited a new investigator, Dr. James Collins, whose pilot work at HRCA has led to his proposal. The RNH projects include: Aging, Anti-hypertensive Therapy and BP Regulation by Lewis A. Lipsitz, M.D; Pathogenesis of Detrusor Over-activity by Neil M. Resnick, M.D; Interventions to Improve Motor Control in Frail Elderly by James J. Collins; Ph.D. The projects will be supported by Cores to support subject recruitment, data management and analysis; and to assure efficient program operation and promote new research and training. An advisory group of academic leaders in medicine and nursing will review the program annually and help set its future course. The commitment of substantial institutional resources, a successful 15-year collaboration among investigators, a track record of productivity, a consortium of outstanding academic centers, and proven leadership abilities of administrative staff, all assure that this program will achieve its goals.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG004390-17
Application #
6167983
Study Section
Special Emphasis Panel (ZAG1-BJB-4 (J1))
Program Officer
Premen, Andre J
Project Start
1983-09-29
Project End
2004-03-31
Budget Start
2000-04-01
Budget End
2001-03-31
Support Year
17
Fiscal Year
2000
Total Cost
$1,322,434
Indirect Cost
Name
Hebrew Rehabilitation Center for Aged
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02131
Thapa, Saurja; Shmerling, Robert H; Bean, Jonathan F et al. (2018) Chronic multisite pain: evaluation of a new geriatric syndrome. Aging Clin Exp Res :
Thakral, Manu; Shi, Ling; Foust, Janice B et al. (2018) Persistence of pain quality in community-dwelling older adults with chronic non-cancer pain. Geriatr Nurs 39:450-456
van der Leeuw, Guusje; Leveille, Suzanne G; Dong, Zhiyong et al. (2018) Chronic Pain and Attention in Older Community-Dwelling Adults. J Am Geriatr Soc 66:1318-1324
Lipsitz, Lewis A; Manor, Brad; Habtemariam, Daniel et al. (2018) The pace and prognosis of peripheral sensory loss in advanced age: association with gait speed and falls. BMC Geriatr 18:274
Veronese, Nicola; Cereda, Emanuele; Stubbs, Brendon et al. (2017) Risk of cardiovascular disease morbidity and mortality in frail and pre-frail older adults: Results from a meta-analysis and exploratory meta-regression analysis. Ageing Res Rev 35:63-73
Nawai, Ampicha; Leveille, Suzanne G; Shmerling, Robert H et al. (2017) Pain severity and pharmacologic pain management among community-living older adults: the MOBILIZE Boston study. Aging Clin Exp Res 29:1139-1147
van der Leeuw, Guusje; Leveille, Suzanne G; Jones, Richard N et al. (2017) Measuring attention in very old adults using the Test of Everyday Attention. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 24:543-554
van der Leeuw, Guusje; Eggermont, Laura H P; Shi, Ling et al. (2016) Pain and Cognitive Function Among Older Adults Living in the Community. J Gerontol A Biol Sci Med Sci 71:398-405
Foley, Jessica M; Salat, David H; Stricker, Nikki H et al. (2016) Glucose Dysregulation Interacts With APOE-?4 to Potentiate Temporoparietal Cortical Thinning. Am J Alzheimers Dis Other Demen 31:76-86
Thakral, Manu; Shi, Ling; Foust, Janice B et al. (2016) Pain quality descriptors in community-dwelling older adults with nonmalignant pain. Pain 157:2834-2842

Showing the most recent 10 out of 312 publications