This program continues investigations on several aspects of the biology of aging cells and tissues. Certain aspects of biochemical and biomolecular processes which are age-dependent are being examined and include: a) vitamin K-dependent protein carboxylation and the synthesis of the bone protein, osteocalcin; b) osteocalcin and its relationships to the lipid-soluble vitamins in osteoporosis and other bone disorders; c) polyamine-dependent lysyl residue aminobutylation and hydroxylation and the synthesis of an 18,000 dalton hypusine-containing protein, which is a measure of cell proliferative capacity; d) lipoprotein metabolism and the aging process and the continued characterization of genes which code for certain apolipoproteins; e) the design and use of certain vital reagents which are based on special chemical features found in organoboron and aromatic quaterary compounds and use fluorescence and boron-NMR techniques.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG004727-06
Application #
3090912
Study Section
Aging Review Committee (AGE)
Project Start
1978-05-01
Project End
1988-04-30
Budget Start
1987-05-01
Budget End
1988-04-30
Support Year
6
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
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