Abstract

The investigators propose to isolate, define and quantitate the macromolecular components, collagen, elastin, fibronectin and microfibrillar proteins of the extracellular isomolecular types of macromolecules in each region will be done. Lathyrogens will be used to study aspects of deposition of these components and their functional properties in relation to crosslinkage of collagen and elastin. The cells responsible for matrix production will be evaluated and modulation by a variety of factors will be examined. Regulatory processes of deposition and remodeling of the matrix during development, aging and myopathy also will be studied. In addition, phosphorylation of hydroxylysine as a possible regulation process in production and deposition of the matrix will be studied.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG005554-03
Application #
3821839
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Albert Einstein College of Medicine
Department
Type
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461

  Publications

Takahashi, S; Geenen, D; Nieves, E et al. (1999) Collagenase degrades collagen in vivo in the ischemic heart. Biochim Biophys Acta 1428:251-9
Luangkhot, R; Rutchik, S; Agarwal, V et al. (1992) Collagen alterations in the corpus cavernosum of men with sexual dysfunction. J Urol 148:467-71
Takahashi, S; Zhao, M; Eng, C (1991) Isolation and characterization of insoluble collagen of dog hearts. Protein Expr Purif 2:304-12
Zeydel, M; Puglia, K; Eghbali, M et al. (1991) Properties of heart fibroblasts of adult rats in culture. Cell Tissue Res 265:353-9
Skrivanek, J A; Schwartz, E; Blumenfeld, O O et al. (1990) Ascorbate-induced changes in gangliosides of calf aortic smooth muscle cells in culture: possible influence of extracellular matrix. In Vitro Cell Dev Biol 26:502-6
Eghbali, M (1989) Cellular origin and distribution of transforming growth factor-beta in the normal rat myocardium. Cell Tissue Res 256:553-8
Eghbali, M; Eghbali, M; Robinson, T F et al. (1989) Collagen accumulation in heart ventricles as a function of growth and aging. Cardiovasc Res 23:723-9
Eghbali, M; Blumenfeld, O O; Seifter, S et al. (1989) Localization of types I, III and IV collagen mRNAs in rat heart cells by in situ hybridization. J Mol Cell Cardiol 21:103-13
Eghbali, M; Silman, I; Robinson, T F et al. (1988) Visualization of collagenase-sensitive acetylcholinesterase in isolated cardiomyocytes and in heart tissue. Cell Tissue Res 253:281-6
Eghbali, M; Czaja, M J; Zeydel, M et al. (1988) Collagen chain mRNAs in isolated heart cells from young and adult rats. J Mol Cell Cardiol 20:267-76

Showing the most recent 10 out of 14 publications