Abstract

We have shown a relationship between estrogen levels, estrogen production and bone mass in peri- and postmenopausal women. There is also evidence that androgens may influence bone mass in such women. Therefore, as the Steroid Core we wish to continue measurements of hormone levels in the groups of women enrolled in the study and to extend these measurements to black women, twins, and aging men in support of the proposals in the Progra Project. We also wish to confirm our measurements of steroid dynamics in the pre-, peri-, and post-menopausal women whom we have been following.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG005793-09
Application #
3745827
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202

  Publications

Hui, Siu L; Perkins, Anthony J; Harezlak, Jaroslaw et al. (2010) Velocities of bone mineral accrual in black and white American children. J Bone Miner Res 25:1527-35
Ruppel, Meghan E; Burr, David B; Miller, Lisa M (2006) Chemical makeup of microdamaged bone differs from undamaged bone. Bone 39:318-24
Mashiba, T; Hui, S; Turner, C H et al. (2005) Bone remodeling at the iliac crest can predict the changes in remodeling dynamics, microdamage accumulation, and mechanical properties in the lumbar vertebrae of dogs. Calcif Tissue Int 77:180-5
McCabe, Linda D; Martin, Berdine R; McCabe, George P et al. (2004) Dairy intakes affect bone density in the elderly. Am J Clin Nutr 80:1066-74
Day, J S; Ding, M; Bednarz, P et al. (2004) Bisphosphonate treatment affects trabecular bone apparent modulus through micro-architecture rather than matrix properties. J Orthop Res 22:465-71
Ding, M; Day, J S; Burr, D B et al. (2003) Canine cancellous bone microarchitecture after one year of high-dose bisphosphonates. Calcif Tissue Int 72:737-44
Burr, David B; Miller, Lisa; Grynpas, Marc et al. (2003) Tissue mineralization is increased following 1-year treatment with high doses of bisphosphonates in dogs. Bone 33:960-9
Burr, D B (2002) Targeted and nontargeted remodeling. Bone 30:2-4
Li, J; Mashiba, T; Burr, D B (2001) Bisphosphonate treatment suppresses not only stochastic remodeling but also the targeted repair of microdamage. Calcif Tissue Int 69:281-6
Mashiba, T; Turner, C H; Hirano, T et al. (2001) Effects of high-dose etidronate treatment on microdamage accumulation and biomechanical properties in beagle bone before occurrence of spontaneous fractures. Bone 29:271-8

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