Abstract

The Clinical Core occupies a central role to the accomplishments of the Program Project and Individual Clinical Projects. Specifically, this Core will: 1) Provide long-term follow-up of previously recruited patient populations, 2) Recruit (for the Individual Projects) and provide long-term follow-up of new """"""""Special Populations"""""""" of Alzheimer's Disease (AD) patients, including minority AD patients (American Black), AD patients with a concurrent depression, and AD patients with desired SPECT scans (normal, unilateral/focal abnormalities, """"""""classic"""""""" changes), 3) Assist in the acquisition of tissue for the Tissue Procurement Immunocytochemistry Core, and 4) Provide data management and biostatistical services.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG006569-06
Application #
3790189
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Type
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Bambara, Jennifer K; Griffith, H Randall; Martin, Roy C et al. (2007) Medical decision-making abilities in older adults with chronic partial epilepsy. Epilepsy Behav 10:63-8
Huthwaite, Justin S; Martin, Roy C; Griffith, H Randall et al. (2006) Declining medical decision-making capacity in mild AD: a two-year longitudinal study. Behav Sci Law 24:453-63
Dresbach, Thomas; Torres, Viviana; Wittenmayer, Nina et al. (2006) Assembly of active zone precursor vesicles: obligatory trafficking of presynaptic cytomatrix proteins Bassoon and Piccolo via a trans-Golgi compartment. J Biol Chem 281:6038-47
Griffith, H R; Dymek, M P; Atchison, P et al. (2005) Medical decision-making in neurodegenerative disease: mild AD and PD with cognitive impairment. Neurology 65:483-5
van Groen, Thomas; Kadish, Inga; Wyss, J Michael (2004) Retrosplenial cortex lesions of area Rgb (but not of area Rga) impair spatial learning and memory in the rat. Behav Brain Res 154:483-91
Stevens, Alan; Owen, Jason; Roth, David et al. (2004) Predictors of time to nursing home placement in White and African American individuals with dementia. J Aging Health 16:375-97
Wyss, J Michael; Kadish, Inga; van Groen, Thomas (2003) Age-related decline in spatial learning and memory: attenuation by captopril. Clin Exp Hypertens 25:455-74
Roysommuti, S; Carroll, S L; Wyss, J M (2003) Neuregulin-1beta modulates in vivo entorhinal-hippocampal synaptic transmission in adult rats. Neuroscience 121:779-85
Fenster, Steven D; Kessels, Michael M; Qualmann, Britta et al. (2003) Interactions between Piccolo and the actin/dynamin-binding protein Abp1 link vesicle endocytosis to presynaptic active zones. J Biol Chem 278:20268-77
Kim, Seho; Ko, Jaewon; Shin, Hyewon et al. (2003) The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo. J Biol Chem 278:6291-300

Showing the most recent 10 out of 147 publications