Abstract

The roles of the Neuropathology and Genotyping Core are to promote brain availability for research, and to extract DNA from peripheral blood samples and carry out genotyping at loci implicated in Alzheimer's disease (AD). Thus, the general aims include performing a thorough postmortem examination, harvesting as many samples as possible for research from each brain donated (Vonsattel laboratory), and accessioning blood samples, extracting genomic DNA, and carrying out PCR amplification and genotyping for APOE, TP73 and PDE4D single-nucleotide polymorphisms (SNPs) (Tycko laboratory).
The specific aims of the Core are: - To establish an accurate diagnosis on all autopsy brains obtained for this project. - To prepare cryopreserved samples from defined anatomical regions of the brains according to standardized protocols. - To build a library of paraffin embedded tissue of precise brain areas from these same autopsy cases. - To extract genomic DNA from blood samples of AD cases and controls. - To perform PCR amplification and genotyping ofAPOE, TP73 and PDE4D SNPs. The Core will provide tissues and genotypes for project l (Dr. Mayeux), project 2 (Dr. Luchsinger), project 4 (Dr. Louis), and project 5 (Dr. Devanand).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG007232-18
Application #
7254205
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
18
Fiscal Year
2006
Total Cost
$25,000
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Zahodne, Laura B; Watson, Caitlin W-M; Seehra, Sonia et al. (2018) Positive Psychosocial Factors and Cognition in Ethnically Diverse Older Adults. J Int Neuropsychol Soc 24:294-304
Zahodne, Laura B; Schupf, Nicole; Brickman, Adam M (2018) Control beliefs are associated with preserved memory function in the face of low hippocampal volume among diverse older adults. Brain Imaging Behav 12:1112-1120
Rizvi, Batool; Narkhede, Atul; Last, Briana S et al. (2018) The effect of white matter hyperintensities on cognition is mediated by cortical atrophy. Neurobiol Aging 64:25-32
Winawer, Melodie R; Griffin, Nicole G; Samanamud, Jorge et al. (2018) Somatic SLC35A2 variants in the brain are associated with intractable neocortical epilepsy. Ann Neurol 83:1133-1146
Gu, Yian; Manly, Jennifer J; Mayeux, Richard P et al. (2018) An Inflammation-related Nutrient Pattern is Associated with Both Brain and Cognitive Measures in a Multiethnic Elderly Population. Curr Alzheimer Res 15:493-501
Noble, James M; Schupf, Nicole; Manly, Jennifer J et al. (2017) Secular Trends in the Incidence of Dementia in a Multi-Ethnic Community. J Alzheimers Dis 60:1065-1075
Last, Briana S; García Rubio, Maria-José; Zhu, Carolyn W et al. (2017) Medicare Expenditure Correlates of Atrophy and Cerebrovascular Disease in Older Adults. Exp Aging Res 43:149-160
Gu, Yian; Vorburger, Robert; Scarmeas, Nikolaos et al. (2017) Circulating inflammatory biomarkers in relation to brain structural measurements in a non-demented elderly population. Brain Behav Immun 65:150-160
Sachdev, Perminder S; Lo, Jessica W; Crawford, John D et al. (2017) STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease. Alzheimers Dement (Amst) 7:11-23
Devanand, Davangere P; Liu, Xinhua; Brown, Patrick J (2017) Impact of Functional Deficits in Instrumental Activities of Daily Living in Mild Cognitive Impairment: A Clinical Algorithm to Predict Progression to Dementia. Alzheimer Dis Assoc Disord 31:55-61

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