Abstract

proposal.) This Core participates in the design of experiments and interpretation of results, coordinates animal studies, houses animals to prevent intercurrent disease, and monitors animal health. All rats will be obtained through the NIA, and maintained under isolation conditions to prevent intercurrent infectious diseases. The Core utilizes established programs in laboratory animal medicine and pathology to assess the disease status of the rats. This is considered critical for distinguishing between age effects and disease processes resulting from infection or environmental factors.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG008321-11
Application #
6424495
Study Section
Project Start
2001-04-01
Project End
2003-03-31
Budget Start
Budget End
Support Year
11
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Jervis, Kathryn M; Robaire, Bernard (2004) The effects of long-term vitamin E treatment on gene expression and oxidative stress damage in the aging Brown Norway rat epididymis. Biol Reprod 71:1088-95
Zubkova, Ekaterina V; Robaire, Bernard (2004) Effect of glutathione depletion on antioxidant enzymes in the epididymis, seminal vesicles, and liver and on spermatozoa motility in the aging brown Norway rat. Biol Reprod 71:1002-8
Anway, Matthew D; Folmer, Janet; Wright, William W et al. (2003) Isolation of sertoli cells from adult rat testes: an approach to ex vivo studies of Sertoli cell function. Biol Reprod 68:996-1002
Ezer, Nadine; Robaire, Bernard (2003) Gene expression is differentially regulated in the epididymis after orchidectomy. Endocrinology 144:975-88
Jervis, Kathryn M; Robaire, Bernard (2002) Changes in gene expression during aging in the Brown Norway rat epididymis. Exp Gerontol 37:897-906
Banerjee, Partha P; Banerjee, Subhadra; Brown, Terry R (2002) Bcl-2 protein expression correlates with cell survival and androgen independence in rat prostatic lobes. Endocrinology 143:1825-32
Chen, Haolin; Hardy, Matthew P; Zirkin, Barry R (2002) Age-related decreases in Leydig cell testosterone production are not restored by exposure to LH in vitro. Endocrinology 143:1637-42
Culty, Martine; Luo, Lindi; Yao, Zhi-Xing et al. (2002) Cholesterol transport, peripheral benzodiazepine receptor, and steroidogenesis in aging Leydig cells. J Androl 23:439-47
Luo, L; Chen, H; Zirkin, B R (2001) Leydig cell aging: steroidogenic acute regulatory protein (StAR) and cholesterol side-chain cleavage enzyme. J Androl 22:149-56
Jervis, K M; Robaire, B (2001) Dynamic changes in gene expression along the rat epididymis. Biol Reprod 65:696-703

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