Will life expectancy in the United States and other developed countries level off at about 85 years or continue to increase to a century or more? This research project is designed to address this controversy through theory-based model building and statistical analysis of two data sets -- from the U.S. and Sweden - - that will be rigorously checked for reliability an published in full to aid future researchers. Specifically, the proposed research will: (1) specify mathematical models that are consistent with the underlying concepts of the alternative """"""""limited-lifespan"""""""" and """"""""mortality-reduction"""""""" paradigms: (2) contrast the implications of the models about (a) the shape of the age-trajectory of the force of mortality at advanced ages, and (3) compile, critically examine, and publish in full two data sets on age-specific mortality at older ages, pertaining to Sweden and to U.S. medicare enrollees: and (4) using maximum likelihood estimation, determine how well the alternative models fit the date.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
7P01AG008761-03
Application #
3790341
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Jensen, Magnus T; Wod, Mette; Galatius, Søren et al. (2018) Heritability of resting heart rate and association with mortality in middle-aged and elderly twins. Heart 104:30-36
Pahlen, Shandell; Hamdi, Nayla R; Dahl Aslan, Anna K et al. (2018) Age-Moderation of Genetic and Environmental Contributions to Cognitive Functioning in Mid- and Late-Life for Specific Cognitive Abilities. Intelligence 68:70-81
Mengel-From, Jonas; Rønne, Mette E; Carlsen, Anting L et al. (2018) Circulating, Cell-Free Micro-RNA Profiles Reflect Discordant Development of Dementia in Monozygotic Twins. J Alzheimers Dis 63:591-601
Saunders, Gretchen R B; Elkins, Irene J; Christensen, Kaare et al. (2018) The relationship between subjective well-being and mortality within discordant twin pairs from two independent samples. Psychol Aging 33:439-447
Debrabant, Birgit; Soerensen, Mette; Christiansen, Lene et al. (2018) DNA methylation age and perceived age in elderly Danish twins. Mech Ageing Dev 169:40-44
Dato, Serena; Soerensen, Mette; De Rango, Francesco et al. (2018) The genetic component of human longevity: New insights from the analysis of pathway-based SNP-SNP interactions. Aging Cell 17:e12755
Svane, Anne Marie; Soerensen, Mette; Lund, Jesper et al. (2018) DNA Methylation and All-Cause Mortality in Middle-Aged and Elderly Danish Twins. Genes (Basel) 9:
Pedersen, Jacob K; Elo, Irma T; Schupf, Nicole et al. (2017) The Survival of Spouses Marrying Into Longevity-Enriched Families. J Gerontol A Biol Sci Med Sci 72:109-114
Flachsbart, Friederike; Dose, Janina; Gentschew, Liljana et al. (2017) Identification and characterization of two functional variants in the human longevity gene FOXO3. Nat Commun 8:2063
Fagan, Erin; Sun, Fangui; Bae, Harold et al. (2017) Telomere length is longer in women with late maternal age. Menopause 24:497-501

Showing the most recent 10 out of 445 publications