Project 2: Oldest-Old Mortality and Disability Among Danish Twins This research project is designed to extend the Danish Twin Register in three directions, involving different-sex DZ twins, causes of death, and ADLs. The new data will be carefully checked, achieved, and published in full to aid other researchers. In addition, the new data, together with existing data, will be analyzed to better understand genetic factors underlying trajectories of mortality. Specifically, we will: Update and computerized data on different-sex DZ twins born between 1870 and 1910, merge these data with the existing data base on MZ and same-sex DZ twins, and then analyze these data to better understand mortality patterns for men vs. women, as well as studying special characteristics of different-sex DZ twins compared with same-sex MZ and DZ twins. Link the Danish Twin Register with the Danish Cause-of-Death Register to obtain proximate, underlying, and contribute causes of death for all twins who died since 2943, and then analyze these data to uncover genetic factors and common-childhood-environment factors underlying causes (or groups of causes) of death that are correlated for MZ and DZ twins. Collect and computerize data on the health and disability of elderly Danish twins in 1995 and again two years later, and then analyze these data to uncover genetic factors and common-childhood-environment factors underlying health and disability patterns and subsequently mortality.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG008761-09
Application #
6267456
Study Section
Project Start
1998-08-15
Project End
1998-12-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
9
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Debrabant, Birgit; Soerensen, Mette; Christiansen, Lene et al. (2018) DNA methylation age and perceived age in elderly Danish twins. Mech Ageing Dev 169:40-44
Dato, Serena; Soerensen, Mette; De Rango, Francesco et al. (2018) The genetic component of human longevity: New insights from the analysis of pathway-based SNP-SNP interactions. Aging Cell 17:e12755
Svane, Anne Marie; Soerensen, Mette; Lund, Jesper et al. (2018) DNA Methylation and All-Cause Mortality in Middle-Aged and Elderly Danish Twins. Genes (Basel) 9:
Jensen, Magnus T; Wod, Mette; Galatius, Søren et al. (2018) Heritability of resting heart rate and association with mortality in middle-aged and elderly twins. Heart 104:30-36
Pahlen, Shandell; Hamdi, Nayla R; Dahl Aslan, Anna K et al. (2018) Age-Moderation of Genetic and Environmental Contributions to Cognitive Functioning in Mid- and Late-Life for Specific Cognitive Abilities. Intelligence 68:70-81
Mengel-From, Jonas; Rønne, Mette E; Carlsen, Anting L et al. (2018) Circulating, Cell-Free Micro-RNA Profiles Reflect Discordant Development of Dementia in Monozygotic Twins. J Alzheimers Dis 63:591-601
Saunders, Gretchen R B; Elkins, Irene J; Christensen, Kaare et al. (2018) The relationship between subjective well-being and mortality within discordant twin pairs from two independent samples. Psychol Aging 33:439-447
Pedersen, Jacob K; Elo, Irma T; Schupf, Nicole et al. (2017) The Survival of Spouses Marrying Into Longevity-Enriched Families. J Gerontol A Biol Sci Med Sci 72:109-114
Flachsbart, Friederike; Dose, Janina; Gentschew, Liljana et al. (2017) Identification and characterization of two functional variants in the human longevity gene FOXO3. Nat Commun 8:2063
Fagan, Erin; Sun, Fangui; Bae, Harold et al. (2017) Telomere length is longer in women with late maternal age. Menopause 24:497-501

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