Abstract

This Core, the Neuroscience Core, is designed to facilitate the research conducted in each of the Projects of this Program Project Grant (PPG) by providing assistance and support for a number of core activities that are common to Projects 0007-0010. Since all 4 Projects will require new or different antibodies as essential tools for the proposed studies, a major activity of the Core will be the generation, characterization and provision of antibody probes to all investigators in this PPG. Since Projects 0007, 0009, and 0010 will use a variety of single transgenic (TG) and bigenic mice overexpressing wild type and mutant alpha-synuclein and other proteins as well as alpha-synuclein knockout mice in their proposed studies, this Core will maintain small cohorts of these well-characterized TG mouse lines to supplement the needs of the different Projects as required for successful completion of the experiments proposed in the PPG. This Core will also continue to serve as a repository for all cDNAs related to this PPG. In summary, by providing for several essential scientific needs of all of the Projects in this PPG, the Neuroscience Core will play a vital role in contributing to the successful accomplishment of the research goals of this PPG.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG009215-19
Application #
7616499
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2008-05-01
Budget End
2009-04-30
Support Year
19
Fiscal Year
2008
Total Cost
$148,028
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Tosto, Giuseppe; Monsell, Sarah E; Hawes, Stephen E et al. (2015) Pattern of extrapyramidal signs in Alzheimer's disease. J Neurol 262:2548-56
Paumier, Katrina L; Luk, Kelvin C; Manfredsson, Fredric P et al. (2015) Intrastriatal injection of pre-formed mouse ?-synuclein fibrils into rats triggers ?-synuclein pathology and bilateral nigrostriatal degeneration. Neurobiol Dis 82:185-199
Kalia, Lorraine V; Lang, Anthony E; Hazrati, Lili-Naz et al. (2015) Clinical correlations with Lewy body pathology in LRRK2-related Parkinson disease. JAMA Neurol 72:100-5
Mata, Ignacio F; Leverenz, James B; Weintraub, Daniel et al. (2014) APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease. JAMA Neurol 71:1405-12
Motsinger-Reif, Alison A; Zhu, Hongjie; Kling, Mitchel A et al. (2013) Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer's disease from normal cognitive aging. Acta Neuropathol Commun 1:28
Arnold, Steven E; Toledo, Jon B; Appleby, Dina H et al. (2013) Comparative survey of the topographical distribution of signature molecular lesions in major neurodegenerative diseases. J Comp Neurol 521:4339-55
Kaddurah-Daouk, R; Zhu, H; Sharma, S et al. (2013) Alterations in metabolic pathways and networks in Alzheimer's disease. Transl Psychiatry 3:e244
Couthouis, Julien; Hart, Michael P; Erion, Renske et al. (2012) Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis. Hum Mol Genet 21:2899-911
Hu, William T; Holtzman, David M; Fagan, Anne M et al. (2012) Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease. Neurology 79:897-905
Chen-Plotkin, Alice S; Unger, Travis L; Gallagher, Michael D et al. (2012) TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways. J Neurosci 32:11213-27

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