Abstract

The neuropathology core will provide diagnostic services as will as serving as a central source of pathological specimens for the research projects. The core will handle all neuropathological specimens derived from subjects included in the clinical core. Close linkage will be maintained with the clinical core so that clinical information is conveyed with pathological specimens and so that diagnostic information and results of specialized research studies are available to clinical researchers. Autopsy brains will be obtained as quickly as possible following death by the Project Leader will the help of an on-call autopsy technician and pathology resident. The brains will be sampled while fresh for diagnosis, electron microscopy, and formalin fixation for immunohistochemistry. The remaining brain will be placed in a -70o C freezer for future research studies. The Project Leader and Co-Leader will establish priority for distribution of this tissue and for special protocols to be performed on the fresh tissue as needed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG009466-04
Application #
3746075
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Rush University Medical Center
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60612

  Publications

Mahady, Laura J; Perez, Sylvia E; Emerich, Dwaine F et al. (2017) Cholinergic profiles in the Goettingen miniature pig (Sus scrofa domesticus) brain. J Comp Neurol 525:553-573
Cade, Brian E; Gottlieb, Daniel J; Lauderdale, Diane S et al. (2016) Common variants in DRD2 are associated with sleep duration: the CARe consortium. Hum Mol Genet 25:167-79
Mufson, Elliott J; Malek-Ahmadi, Michael; Perez, Sylvia E et al. (2016) Braak staging, plaque pathology, and APOE status in elderly persons without cognitive impairment. Neurobiol Aging 37:147-153
Lim, Andrew S P; Bennett, David A; Buchman, Aron S (2016) Response to Letter Regarding Article, ""Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People"". Stroke 47:e175
Lim, Andrew S P; Yu, Lei; Schneider, Julie A et al. (2016) Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People. Stroke 47:516-8
Perez, Sylvia E; He, Bin; Nadeem, Muhammad et al. (2015) Resilience of precuneus neurotrophic signaling pathways despite amyloid pathology in prodromal Alzheimer's disease. Biol Psychiatry 77:693-703
Ramanan, Vijay K; Risacher, Shannon L; Nho, Kwangsik et al. (2015) GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP. Brain 138:3076-88
Beckett, Laurel A; Donohue, Michael C; Wang, Cathy et al. (2015) The Alzheimer's Disease Neuroimaging Initiative phase 2: Increasing the length, breadth, and depth of our understanding. Alzheimers Dement 11:823-31
Sohail, Shahmir; Yu, Lei; Bennett, David A et al. (2015) Irregular 24-hour activity rhythms and the metabolic syndrome in older adults. Chronobiol Int 32:802-13
Alldred, Melissa J; Lee, Sang Han; Petkova, Eva et al. (2015) Expression profile analysis of hippocampal CA1 pyramidal neurons in aged Ts65Dn mice, a model of Down syndrome (DS) and Alzheimer's disease (AD). Brain Struct Funct 220:2983-96

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