The goals of the Clinical Core are (1) to recruit and thoroughly evaluate persons with Alzheimer's disease and unaffected individuals, (2) to determine eligibility for and distribute appropriate participants to the two proposed clinical projects, and (3) to follow a subset of these persons who agree to brain autopsy with annual re-evaluations to assure timely assessment of clinical status proximate to death for the three proposed clinical-pathologic projects. The ability of Clinical Core to meet these goals, will be greatly facilitated by the Clinical and Religious orders Study. The ability of Clinical Core to meet these goals, will be greatly facilitated by the Clinical and Religious orders Study (ROS) Cores of the existing Rush ADCC. Specifically, since March 2, 1992, these two cores of the Rush ADCC have evaluated 2217 persons. The clinical evaluations are uniform and structured and the diagnosis of probable AD conforms to the recommendations of the NINCDS/ADRDA Workgroup. The Rush ADCC is staffed by skilled neurologists and neuropsychologists with extensive experience in the evaluation of persons with dementia, and a supporting staff skilled in adapting evaluations to the needs of the patients, their families, and friends, and coordinating multiple studies.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG009466-07
Application #
6234263
Study Section
Project Start
1997-04-01
Project End
1998-03-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
7
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Rush University Medical Center
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60612
Mahady, Laura J; Perez, Sylvia E; Emerich, Dwaine F et al. (2017) Cholinergic profiles in the Goettingen miniature pig (Sus scrofa domesticus) brain. J Comp Neurol 525:553-573
Lim, Andrew S P; Bennett, David A; Buchman, Aron S (2016) Response to Letter Regarding Article, ""Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People"". Stroke 47:e175
Lim, Andrew S P; Yu, Lei; Schneider, Julie A et al. (2016) Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People. Stroke 47:516-8
Cade, Brian E; Gottlieb, Daniel J; Lauderdale, Diane S et al. (2016) Common variants in DRD2 are associated with sleep duration: the CARe consortium. Hum Mol Genet 25:167-79
Mufson, Elliott J; Malek-Ahmadi, Michael; Perez, Sylvia E et al. (2016) Braak staging, plaque pathology, and APOE status in elderly persons without cognitive impairment. Neurobiol Aging 37:147-153
Perez, Sylvia E; He, Bin; Nadeem, Muhammad et al. (2015) Resilience of precuneus neurotrophic signaling pathways despite amyloid pathology in prodromal Alzheimer's disease. Biol Psychiatry 77:693-703
Ramanan, Vijay K; Risacher, Shannon L; Nho, Kwangsik et al. (2015) GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP. Brain 138:3076-88
Beckett, Laurel A; Donohue, Michael C; Wang, Cathy et al. (2015) The Alzheimer's Disease Neuroimaging Initiative phase 2: Increasing the length, breadth, and depth of our understanding. Alzheimers Dement 11:823-31
Sohail, Shahmir; Yu, Lei; Bennett, David A et al. (2015) Irregular 24-hour activity rhythms and the metabolic syndrome in older adults. Chronobiol Int 32:802-13
Alldred, Melissa J; Lee, Sang Han; Petkova, Eva et al. (2015) Expression profile analysis of hippocampal CA1 pyramidal neurons in aged Ts65Dn mice, a model of Down syndrome (DS) and Alzheimer's disease (AD). Brain Struct Funct 220:2983-96

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