Aging Auditory System: Presbycusis & its Neural Bases. The process of aging in modern, technologically advanced societies is accompanied by a progressive hearing impairment known as presbycusis. This age-related disorder often causes significant communication problems in persons who have had no previous hearing or speech deficits, resulting in impaired relationships at home and in the workplace, as well as increases costs to the individual, their family and society. Key aspects and neural etiologies of age-related hearing loss are poorly understood despite the fact that 30% of persons age 65-74 and 50% of persons 75 and older suffer from significant hearing impairment; stated another way, after reaching age 60 years, the percentage of the population experiencing difficulty in perceiving speech doubles per decade; 16% at 60, 32% at 70, 64% at 80, and virtually everyone beyond the mid-eighty years. The major theme of this proposal is to increase our knowledge of auditory processing deficits of presbycusis and advance our understanding of the neural bases of this aging disorder. Special attention is paid to distinguishing the effects of peripheral hearing loss and central aging effects in presbycusis. This proposal puts forth a five-year series of interrelated hypotheses tested with tightly coupled and truly interdisciplinary experimental methodologies. Disciplines of psychoacoustics, speech perception, audiology, evoked-potential neurophysiology, and reflex psychology are brought to bear on testing hypotheses in human subject populations to further characterize presbycusis. Scientific disciplines of reflex psychology, gross-potential and single-unit neurophysiology, and neuroanatomy at light and electron microscopic levels test hypotheses utilizing animal populations. These investigations in mammals examine the neural bases of hearing loss resulting from aging effects i the peripheral and central auditory systems. In both human and animal populations, comparisons will be made between young and old subject groups to determine aging effect in hearing loss, and comparisons will be made between subjects with cochlear losses and those with normal hearing to assess the effects of peripheral hearing loss in presbycusis. Special attention will be paid to interdisciplinary, repeated-measures experimental designs, quantitative multivariate data analyses, and determining the effects of different types of background noise on neural and perceptual processing. It is hoped that testing hypotheses put forth in the present proposal concerning the neural bases of age related hearing loss will eventually lead to medical interventions that prevent, alleviate or minimize the communication problems of presbycusis.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG009524-02
Application #
3091276
Study Section
Biological and Clinical Aging Review Committee (BCA)
Project Start
1992-05-01
Project End
1997-03-31
Budget Start
1993-04-01
Budget End
1994-03-31
Support Year
2
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Rochester Institute of Technology
Department
Type
Organized Research Units
DUNS #
City
Rochester
State
NY
Country
United States
Zip Code
14623
Eddins, Ann Clock; Ozmeral, Erol J; Eddins, David A (2018) How aging impacts the encoding of binaural cues and the perception of auditory space. Hear Res 369:79-89
Hoover, Eric C; Eddins, Ann C; Eddins, David A (2018) Distribution of spectral modulation transfer functions in a young, normal-hearing population. J Acoust Soc Am 143:306
Eddins, Ann Clock; Eddins, David A (2018) Cortical Correlates of Binaural Temporal Processing Deficits in Older Adults. Ear Hear 39:594-604
Ozmeral, Erol J; Eddins, Ann C; Eddins, David A (2018) How Do Age and Hearing Loss Impact Spectral Envelope Perception? J Speech Lang Hear Res 61:2376-2385
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Bazard, Parveen; Frisina, Robert D; Walton, Joseph P et al. (2017) Nanoparticle-based Plasmonic Transduction for Modulation of Electrically Excitable Cells. Sci Rep 7:7803
Watson, Nathan; Ding, Bo; Zhu, Xiaoxia et al. (2017) Chronic inflammation - inflammaging - in the ageing cochlea: A novel target for future presbycusis therapy. Ageing Res Rev 40:142-148
Brecht, Elliott J; Barsz, Kathy; Gross, Benjamin et al. (2017) Increasing GABA reverses age-related alterations in excitatory receptive fields and intensity coding of auditory midbrain neurons in aged mice. Neurobiol Aging 56:87-99
Halonen, Joshua; Hinton, Ashley S; Frisina, Robert D et al. (2016) Long-term treatment with aldosterone slows the progression of age-related hearing loss. Hear Res 336:63-71

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