The animal core will be responsible for providing all animals for Project 2,3, and 4. This involves ordering young animals in the initial year to found our own colony to provide older animals in later months. Old animals will also be purchased from NIA-subsidized colonies for the first two years, until subjects of suitable ages can be obtained from our own stock. The main reason for aging our own animals is to monitor and control their exposure to noise by keeping them in acoustically controlled conditions. In addition, we wish to maximize the survival of the aging animals by raising them in specific pathogen-free environments. In that regard, we will work closely with the Medical Center Vivarium staff to monitor the health of our populations. Besides the rearing of the subject populations, the animal core will be primarily responsible for documenting the life history of each animal and the experiments in which it participates. It will also establish timetable for scheduling and delivery of animal subjects to the different projects at the appropriate times.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG009524-05
Application #
5204704
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Eddins, Ann Clock; Ozmeral, Erol J; Eddins, David A (2018) How aging impacts the encoding of binaural cues and the perception of auditory space. Hear Res 369:79-89
Hoover, Eric C; Eddins, Ann C; Eddins, David A (2018) Distribution of spectral modulation transfer functions in a young, normal-hearing population. J Acoust Soc Am 143:306
Eddins, Ann Clock; Eddins, David A (2018) Cortical Correlates of Binaural Temporal Processing Deficits in Older Adults. Ear Hear 39:594-604
Ozmeral, Erol J; Eddins, Ann C; Eddins, David A (2018) How Do Age and Hearing Loss Impact Spectral Envelope Perception? J Speech Lang Hear Res 61:2376-2385
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Bazard, Parveen; Frisina, Robert D; Walton, Joseph P et al. (2017) Nanoparticle-based Plasmonic Transduction for Modulation of Electrically Excitable Cells. Sci Rep 7:7803
Watson, Nathan; Ding, Bo; Zhu, Xiaoxia et al. (2017) Chronic inflammation - inflammaging - in the ageing cochlea: A novel target for future presbycusis therapy. Ageing Res Rev 40:142-148
Brecht, Elliott J; Barsz, Kathy; Gross, Benjamin et al. (2017) Increasing GABA reverses age-related alterations in excitatory receptive fields and intensity coding of auditory midbrain neurons in aged mice. Neurobiol Aging 56:87-99
Ozmeral, Erol J; Eddins, Ann C; Frisina Sr, D Robert et al. (2016) Large cross-sectional study of presbycusis reveals rapid progressive decline in auditory temporal acuity. Neurobiol Aging 43:72-8

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