The overall goal of this program project is to characterize auditory deficits associated with presbycusis and to determine their neural bases, thereby enhancing our understanding our understanding of sensorineural hearing problems that have become part of the aging process in modern industrialized societies; and to expedite the application of such knowledge to prevention, early detection, diagnosis and improvement in the treatment of presbycusis and other sensorineural hearing problems. The Administrative Core will serve two major classes of functions: scientific and fiscal. The scientific functions are to aid the investigators in optimizing excellence and progress of each Project towards its goals in part by encouraging interaction not only among the Program participants but also with other scientists whose work is pertinent to the Program. These functions will be achieved through several actions outlined below, including support in the design and analysis of experiments. The fiscal responsibilities will be carried out in a number of ways that include budget preparation for each Core and Project, monitoring the monthly status of these budgets, and communicating this status to the Project and Core Leaders.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG009524-15
Application #
7417774
Study Section
Special Emphasis Panel (ZAG1)
Project Start
2007-05-15
Project End
2008-04-30
Budget Start
2007-05-15
Budget End
2008-04-30
Support Year
15
Fiscal Year
2007
Total Cost
$263,954
Indirect Cost
Name
Rochester Institute of Technology
Department
Type
DUNS #
002223642
City
Rochester
State
NY
Country
United States
Zip Code
14623
Eddins, Ann Clock; Ozmeral, Erol J; Eddins, David A (2018) How aging impacts the encoding of binaural cues and the perception of auditory space. Hear Res 369:79-89
Hoover, Eric C; Eddins, Ann C; Eddins, David A (2018) Distribution of spectral modulation transfer functions in a young, normal-hearing population. J Acoust Soc Am 143:306
Eddins, Ann Clock; Eddins, David A (2018) Cortical Correlates of Binaural Temporal Processing Deficits in Older Adults. Ear Hear 39:594-604
Ozmeral, Erol J; Eddins, Ann C; Eddins, David A (2018) How Do Age and Hearing Loss Impact Spectral Envelope Perception? J Speech Lang Hear Res 61:2376-2385
Walton, Joseph P; Dziorny, Adam C; Vasilyeva, Olga N et al. (2018) Loss of the Cochlear Amplifier Prestin Reduces Temporal Processing Efficacy in the Central Auditory System. Front Cell Neurosci 12:291
Scott, L L; Brecht, E J; Philpo, A et al. (2017) A novel BK channel-targeted peptide suppresses sound evoked activity in the mouse inferior colliculus. Sci Rep 7:42433
Bazard, Parveen; Frisina, Robert D; Walton, Joseph P et al. (2017) Nanoparticle-based Plasmonic Transduction for Modulation of Electrically Excitable Cells. Sci Rep 7:7803
Watson, Nathan; Ding, Bo; Zhu, Xiaoxia et al. (2017) Chronic inflammation - inflammaging - in the ageing cochlea: A novel target for future presbycusis therapy. Ageing Res Rev 40:142-148
Brecht, Elliott J; Barsz, Kathy; Gross, Benjamin et al. (2017) Increasing GABA reverses age-related alterations in excitatory receptive fields and intensity coding of auditory midbrain neurons in aged mice. Neurobiol Aging 56:87-99
Halonen, Joshua; Hinton, Ashley S; Frisina, Robert D et al. (2016) Long-term treatment with aldosterone slows the progression of age-related hearing loss. Hear Res 336:63-71

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