Central to the Program Project are the stocks that have already been created by the Program Director. These are as follows: IV - base stock founded from flies collected in 1975 by P.T. Ives from an endemic Massachusetts population of Drosophila melanogaster; B - five replicates of the base stocks, founded in 1980; O - five populations derived from the IVs, selected for fertility at 10 weeks, founded in 1980; RU, C, and OC - replicated derivatives of the Os that have since undergone selection for early fertility, like Bs, derived in 1985, 1987, and 1989, respectively; D - replicated derivatives of the Os that have undergone selection for increased resistance to desiccation, founded in 1987; SO - replicated derivatives of the Os that have undergone selection for increased resistance to starvation, founded in 1989; SB - replicated derivatives of the Bs that have undergone selection for increased resistance to starvation, founded in 1989; DS - replicated derivatives of the Ds that have undergone selection for resistance to starvation, founded in 1989. The maintenance of these stocks is crucial to the success of all other research projects, both as experimental material and as points of reference for further experiments. The major activities involved include preparation of culture media, handling of flies, and cleaning of culture equipment, primarily glassware. In addition, funds are requested for the communication functions of the project: publication of papers, telecommunications, and travel. These will be allocated from the Core to the individual participants in the Program Project.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG009970-02
Application #
3768446
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Type
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Phelan, John P; Archer, Margaret A; Beckman, Kelly A et al. (2003) Breakdown in correlations during laboratory evolution. I. Comparative analyses of Drosophila populations. Evolution 57:527-35
Archer, Margaret A; Phelan, John P; Beckman, Kelly A et al. (2003) Breakdown in correlations during laboratory evolution. II. Selection on stress resistance in Drosophila populations. Evolution 57:536-43
Joshi, A; Do, M H; Mueller, L D (1999) Poisson distribution of male mating success in laboratory populations of Drosophila melanogaster. Genet Res 73:239-49
Nusbaum, T J; Rose, M R (1999) The effects of nutritional manipulation and laboratory selection on lifespan in Drosophila melanogaster. J Gerontol A Biol Sci Med Sci 54:B192-8
Djawdan, M; Chippindale, A K; Rose, M R et al. (1998) Metabolic reserves and evolved stress resistance in Drosophila melanogaster. Physiol Zool 71:584-94
Gibbs, A G; Chippindale, A K; Rose, M R (1997) Physiological mechanisms of evolved desiccation resistance in Drosophila melanogaster. J Exp Biol 200:1821-32
Williams, A E; Rose, M R; Bradley, T J (1997) CO2 release patterns in Drosophila melanogaster: the effect of selection for desiccation resistance. J Exp Biol 200:615-24
Joshi, A; Shiotsugu, J; Mueller, L D (1996) Phenotypic enhancement of longevity by environmental urea in Drosophila melanogaster. Exp Gerontol 31:533-44
Joshi, A; Knight, C D; Mueller, L D (1996) Genetics of larval urea tolerance in Drosophila melanogaster. Heredity 77 ( Pt 1):33-9
Mueller, L D; Rose, M R (1996) Evolutionary theory predicts late-life mortality plateaus. Proc Natl Acad Sci U S A 93:15249-53

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