Insufficient sleep is a major health and safety problem for young and older adults alike. National polls? indicate that more than a quarter of adults 18-84 years of age regularly sleep less than 7 h per night, with? 15% reporting sleeping less than 6 h per night. The deficits in alertness and performance ability associated? with insufficient sleep can lead to greater risk for automobile accidents, home and workplace accidents, and? on-the-job errors in sleepy individuals. Insufficient sleep can also have a negative effect on the quality of life,? with impacts on irritability, mood, and motivation. There is evidence from acute sleep deprivation studies that? older adults may respond differently to sleep loss than young adults, but studies comparing the response to? chronic sleep restriction in older and young adults have not yet been conducted.? Here, we propose to investigate the consequences of 4 weeks of chronic insufficient sleep on daytime? alertness and performance in older (55-70) and young (18-30) adults. Subjects will be scheduled to sleep an? equivalent of 5 h per 24 h in a forced desynchrony protocol, in order that we can investigate both the? circadian and wake-dependent contributions to alertness and performance across the 4 weeks of sleep? restriction. We will use subjective and objective measures to assess alertness across each waking episode,? and subjects will perform a battery of tasks several times per day to measure the consequences of sleep? restriction on cognitive throughput, sustained attention, reaction time, motivation, mood and short-term? memory. Our study design will allow us to assess independently the impact of time-of-day (circadian phase)? and duration of prior wakefulness, as well as their interactions, on measures of daytime alertness and? performance under conditions of sleep restriction across 4 weeks.? Results from this study have important implications for understanding the consequences of chronic? insufficient sleep in older adults. Most adults regularly fail to get sufficient sleep, but few studies have? attempted to quantify the consequences of chronic insufficient sleep in middle-aged and older people.? Insufficient sleep can have important effects on health, safety, and quality of life. Knowledge of how the? alertness, performance, and memory of healthy older people respond to insufficient sleep will provide a basis? for future research and for advice and recommendations for maintaining health and well-being as we age.

National Institute of Health (NIH)
National Institute on Aging (NIA)
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Special Emphasis Panel (ZAG1)
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Brigham and Women's Hospital
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Leise, Tanya L; Goldberg, Ariella; Michael, John et al. (2018) Recurring circadian disruption alters circadian clock sensitivity to resetting. Eur J Neurosci :
Zitting, Kirsi-Marja; M√ľnch, Mirjam Y; Cain, Sean W et al. (2018) Young adults are more vulnerable to chronic sleep deficiency and recurrent circadian disruption than older adults. Sci Rep 8:11052
McHill, Andrew W; Hull, Joseph T; McMullan, Ciaran J et al. (2018) Chronic Insufficient Sleep Has a Limited Impact on Circadian Rhythmicity of Subjective Hunger and Awakening Fasted Metabolic Hormones. Front Endocrinol (Lausanne) 9:319
Li, Peng; Yu, Lei; Lim, Andrew S P et al. (2018) Fractal regulation and incident Alzheimer's disease in elderly individuals. Alzheimers Dement 14:1114-1125
Todd, William D; Fenselau, Henning; Wang, Joshua L et al. (2018) A hypothalamic circuit for the circadian control of aggression. Nat Neurosci 21:717-724
Naganuma, Fumito; Bandaru, Sathyajit S; Absi, Gianna et al. (2018) Melanin-concentrating hormone neurons contribute to dysregulation of rapid eye movement sleep in narcolepsy. Neurobiol Dis 120:12-20
Asgari-Targhi, Ameneh; Klerman, Elizabeth B (2018) Mathematical modeling of circadian rhythms. Wiley Interdiscip Rev Syst Biol Med :e1439
Kroeger, Daniel; Absi, Gianna; Gagliardi, Celia et al. (2018) Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice. Nat Commun 9:4129
Gottlieb, Daniel J; Ellenbogen, Jeffrey M; Bianchi, Matt T et al. (2018) Sleep deficiency and motor vehicle crash risk in the general population: a prospective cohort study. BMC Med 16:44
Biello, Stephany M; Bonsall, David R; Atkinson, Lynsey A et al. (2018) Alterations in glutamatergic signaling contribute to the decline of circadian photoentrainment in aged mice. Neurobiol Aging 66:75-84

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