Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG010207-08
Application #
6200983
Study Section
Project Start
1999-09-01
Project End
2000-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
8
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Han, Shuhua; Yang, Kaiyong; Ozen, Zeynep et al. (2003) Enhanced differentiation of splenic plasma cells but diminished long-lived high-affinity bone marrow plasma cells in aged mice. J Immunol 170:1267-73
Dal Porto, Joseph M; Haberman, Ann M; Kelsoe, Garnett et al. (2002) Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced. J Exp Med 195:1215-21
Davila, M; Foster, S; Kelsoe, G et al. (2001) A role for secondary V(D)J recombination in oncogenic chromosomal translocations? Adv Cancer Res 81:61-92
Lu, Y F; Singh, M; Cerny, J (2001) Canonical germinal center B cells may not dominate the memory response to antigenic challenge. Int Immunol 13:643-55
Chen, Z; Koralov, S B; Kelsoe, G (2000) Regulation of humoral immune responses by CD21/CD35. Immunol Rev 176:194-204
Chen, Z; Koralov, S B; Kelsoe, G (2000) Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2. J Exp Med 192:1339-52
Takahashi, Y; Cerasoli, D M; Dal Porto, J M et al. (1999) Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice. J Exp Med 190:399-410
Yang, K; Davila, M; Kelsoe, G (1999) Do germinal centers have a role in the generation of lymphomas? Curr Top Microbiol Immunol 246:53-60;discussion 61-2
Song, H; Nie, X; Basu, S et al. (1999) Regulation of VH gene repertoire and somatic mutation in germinal centre B cells by passively administered antibody. Immunology 98:258-66
Dal Porto, J M; Haberman, A M; Shlomchik, M J et al. (1998) Antigen drives very low affinity B cells to become plasmacytes and enter germinal centers. J Immunol 161:5373-81

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