Falls in the elderly are common and are hazardous. Almost one-third of community-dwelling persons 75 or more years old fall each year and more than five percent of those who fall experience fractures. The tendencies of old adults to fall is associated with increases in their postural sway. Both fall and postural sway responses, regardless of underlying psychological, neurological or musculoskeletal disorders, can be quantified in biomechanical terms. Continuation is proposed of research to examine the response biomechanics of the musculoskeletal system in the arrest of impending falls and the maintenance of standing postural balance in the presence of perturbations. Various disturbances of standing posture will be imposed. Sway reactions and stepping reactions will result. Body segment kinematics, myoelectric activities and support surface reactions will be measured. Joint torques will be computed through biomechanical model analyses. The overall objectives of Project 4 are to quantify differences in disturbance response biomechanics among healthy young and old adults and mobility-impaired old adults both with and without Parkinson's Disease. The proposed research will seeks specific biomechanical sources of those differences and relate them to the biomechanical and neuropsychological outcome measures obtained by other Program units. We will test a number of hypotheses concerning these differences. Understanding of how responses to postural perturbations are affected by natural aging, by neuropsychological status and by impairment will enable earlier and more precise detection of declines in mobility-related task performance capabilities. It will show what aspects of impairment are truly critical to postural maintenance in the presence of disturbances and thus lead to improved assessment and intervention.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
3P01AG010542-04S1
Application #
6234393
Study Section
Project Start
1997-06-01
Project End
1998-03-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
4
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Votruba, Kristen L; Persad, Carol; Giordani, Bruno (2016) Cognitive Deficits in Healthy Elderly Population With ""Normal"" Scores on the Mini-Mental State Examination. J Geriatr Psychiatry Neurol 29:126-32
Albin, Roger L; Burke, James F; Koeppe, Robert A et al. (2013) Assessing mild cognitive impairment with amyloid and dopamine terminal molecular imaging. J Nucl Med 54:887-93
Hernandez, Manuel E; Goldberg, Allon; Alexander, Neil B (2010) Decreased muscle strength relates to self-reported stooping, crouching, or kneeling difficulty in older adults. Phys Ther 90:67-74
Kim, Kyu-Jung; Ashton-Miller, James A (2009) Segmental dynamics of forward fall arrests: a system identification approach. Clin Biomech (Bristol, Avon) 24:348-54
Schulz, Brian W; Ashton-Miller, James A; Alexander, Neil B (2008) The effects of age and step length on joint kinematics and kinetics of large out-and-back steps. Clin Biomech (Bristol, Avon) 23:609-18
Schulz, Brian W; Ashton-Miller, James A; Alexander, Neil B (2007) Maximum step length: relationships to age and knee and hip extensor capacities. Clin Biomech (Bristol, Avon) 22:689-96
Schulz, Brian W; Ashton-Miller, James A; Alexander, Neil B (2007) A kinematic analysis of the rapid step test in balance-impaired and unimpaired older women. Gait Posture 25:515-22
Murphy, Susan L; Gretebeck, Kimberlee A; Alexander, Neil B (2007) The bath environment, the bathing task, and the older adult: a review and future directions for bathing disability research. Disabil Rehabil 29:1067-75
Ahmed, Alaa A; Ashton-Miller, James A (2007) On use of a nominal internal model to detect a loss of balance in a maximal forward reach. J Neurophysiol 97:2439-47
Schulz, Brian W; Ashton-Miller, James A; Alexander, Neil B (2006) Can initial and additional compensatory steps be predicted in young, older, and balance-impaired older females in response to anterior and posterior waist pulls while standing? J Biomech 39:1444-53

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