Multiple, as opposed to single impairments are major contributors to falls and increased functional dependency. Examples of these impairments include visual, leg strength, and cognitive impairment. The effect of these impairments is magnified as the demands of a functional task increase. Furthermore, adding more impairments frequently yields a disproportionate increase in disability. Little is known regarding how combinations of impairments contribute to functional disability. Little is known regarding how combinations of impairments contribute to functional disability. Little is known regarding how individuals compensate for their impairments. Our Program data to date suggests that studies of other tasks and techniques are necessary to help explain the complex relationships among impairments, functional task demand and actual task performance. In this Project, we propose a more specific, controlled, and quantitative experimental approach as the next logical step. The goal of this study is to determine how losses in capabilities (strength, visual, and cognitive impairment) affect mobility-task performance (walking speed and stepping accuracy), particularly when mobility-task demands (increasing strength, visual, and cognitive demands) increase. We will study adults aged 60 and other with specific impairments: individuals who have, either singly or in combination, cognitive impairment, visual impairment, and lower extremity weakness. We chose these impairments based on their contribution to disability, falls, fall-related injury, and institutionalization. These individuals will perform walking-related tasks that provide increasing challenge, particularly with respect to their existing impairment. These tasks simulate a number of walking challenges that might be encountered daily by many older adults (such as stepping accurately to avoid an obstacle or slippery surface). These data will suggest the degree to which impairment must be decreased and/or task demand decreased in order to reduce real world functional disability.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
2P01AG010542-05A2
Application #
6267576
Study Section
Project Start
1998-05-01
Project End
1999-03-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
5
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Votruba, Kristen L; Persad, Carol; Giordani, Bruno (2016) Cognitive Deficits in Healthy Elderly Population With ""Normal"" Scores on the Mini-Mental State Examination. J Geriatr Psychiatry Neurol 29:126-32
Albin, Roger L; Burke, James F; Koeppe, Robert A et al. (2013) Assessing mild cognitive impairment with amyloid and dopamine terminal molecular imaging. J Nucl Med 54:887-93
Hernandez, Manuel E; Goldberg, Allon; Alexander, Neil B (2010) Decreased muscle strength relates to self-reported stooping, crouching, or kneeling difficulty in older adults. Phys Ther 90:67-74
Kim, Kyu-Jung; Ashton-Miller, James A (2009) Segmental dynamics of forward fall arrests: a system identification approach. Clin Biomech (Bristol, Avon) 24:348-54
Schulz, Brian W; Ashton-Miller, James A; Alexander, Neil B (2008) The effects of age and step length on joint kinematics and kinetics of large out-and-back steps. Clin Biomech (Bristol, Avon) 23:609-18
Schulz, Brian W; Ashton-Miller, James A; Alexander, Neil B (2007) Maximum step length: relationships to age and knee and hip extensor capacities. Clin Biomech (Bristol, Avon) 22:689-96
Schulz, Brian W; Ashton-Miller, James A; Alexander, Neil B (2007) A kinematic analysis of the rapid step test in balance-impaired and unimpaired older women. Gait Posture 25:515-22
Murphy, Susan L; Gretebeck, Kimberlee A; Alexander, Neil B (2007) The bath environment, the bathing task, and the older adult: a review and future directions for bathing disability research. Disabil Rehabil 29:1067-75
Ahmed, Alaa A; Ashton-Miller, James A (2007) On use of a nominal internal model to detect a loss of balance in a maximal forward reach. J Neurophysiol 97:2439-47
Schulz, Brian W; Ashton-Miller, James A; Alexander, Neil B (2006) Can initial and additional compensatory steps be predicted in young, older, and balance-impaired older females in response to anterior and posterior waist pulls while standing? J Biomech 39:1444-53

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