National Institute of Health (NIH)
National Institute on Aging (NIA)
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Wake Forest University Health Sciences
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Luo, T David; Alton, Timothy B; Apel, Peter J et al. (2016) Effects of age and insulin-like growth factor-1 on rat neurotrophin receptor expression after nerve injury. Muscle Nerve 54:769-75
Tucsek, Zsuzsanna; Toth, Peter; Sosnowska, Danuta et al. (2014) Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease. J Gerontol A Biol Sci Med Sci 69:1212-26
Masser, Dustin R; Bixler, Georgina V; Brucklacher, Robert M et al. (2014) Hippocampal subregions exhibit both distinct and shared transcriptomic responses to aging and nonneurodegenerative cognitive decline. J Gerontol A Biol Sci Med Sci 69:1311-24
Sosnowska, Danuta; Richardson, Chris; Sonntag, William E et al. (2014) A heart that beats for 500 years: age-related changes in cardiac proteasome activity, oxidative protein damage and expression of heat shock proteins, inflammatory factors, and mitochondrial complexes in Arctica islandica, the longest-living noncolonial an J Gerontol A Biol Sci Med Sci 69:1448-61
Toth, Peter; Tarantini, Stefano; Tucsek, Zsuzsanna et al. (2014) Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase. Am J Physiol Heart Circ Physiol 306:H299-308
Csiszar, Anna; Gautam, Tripti; Sosnowska, Danuta et al. (2014) Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats. Am J Physiol Heart Circ Physiol 307:H292-306
Bailey-Downs, Lora C; Tucsek, Zsuzsanna; Toth, Peter et al. (2013) Aging exacerbates obesity-induced oxidative stress and inflammation in perivascular adipose tissue in mice: a paracrine mechanism contributing to vascular redox dysregulation and inflammation. J Gerontol A Biol Sci Med Sci 68:780-92
Warrington, Junie P; Ashpole, Nicole; Csiszar, Anna et al. (2013) Whole brain radiation-induced vascular cognitive impairment: mechanisms and implications. J Vasc Res 50:445-57
Ungvari, Zoltan; Podlutsky, Andrej; Sosnowska, Danuta et al. (2013) Ionizing radiation promotes the acquisition of a senescence-associated secretory phenotype and impairs angiogenic capacity in cerebromicrovascular endothelial cells: role of increased DNA damage and decreased DNA repair capacity in microvascular radiosens J Gerontol A Biol Sci Med Sci 68:1443-57
Ungvari, Zoltan; Csiszar, Anna; Sosnowska, Danuta et al. (2013) Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity: the giant clam (Tridacna derasa). J Gerontol A Biol Sci Med Sci 68:359-67

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