The Methods and Analysis Core has two main functions. First, to supply, operate and maintain the specialized equipment used in individual Research projects for monitoring a variety of overt circadian rhythms in rodents and humans, and to implement standard procedures for their computer storage. The Core also explores and validates novel techniques for non-invasive monitoring of overt circadian rhythms in humans and rodents. A second main function is to provide investigators in all five Projects with standard methods for reporting and analyzing temporal profiles of activity, temperature, sleep stages, hormonal levels, and behavioral variables. The Core also explores and validates novel methods for data analysis that are specially suited to the data obtained in the five Projects. The availability of a centralized pool of monitoring equipment prevents equipment duplication and provides the individual investigators with expert assistance for optimal operation and trouble-shooting of the equipment. The availability of standardized procedures for data reporting and analysis enables each investigator to extract as much information as possible from the collected data, and facilitates the integration of individual projects as well as communication between investigators. Standardization of data processing and analysis enables additional comparisons of various study groups across Projects, and thus more information can be derived from the Program Project as a whole than from the sum of each of its components. This core has also enabled the various projects to incorporate a variety of new approaches for recording and analyzing sleep and circadian rhythms. Of particular significance is the development of new approaches over the past 18 months for; 1) the quantitative analysis of circadian pattern fragmentation, 2) the use of a nw device for monitoring alertness under ambulatory conditions, 3) monitoring a range of cognitive functions, and 4) the recording of EEG and EMG waveforms in the hamster using a state-of- ?he-art system. The use of these and other new approaches developed by t his core will greatly enhance the overall quality and quantity of the data collected in the five projects.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
3P01AG011412-05S2
Application #
6218754
Study Section
Project Start
1999-09-30
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
5
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Morselli, Lisa L; Gamazon, Eric R; Tasali, Esra et al. (2018) Shared Genetic Control of Brain Activity During Sleep and Insulin Secretion: A Laboratory-Based Family Study. Diabetes 67:155-164
Temple, Karla A; Leproult, Rachel; Morselli, Lisa et al. (2018) Sex Differences in the Impact of Obstructive Sleep Apnea on Glucose Metabolism. Front Endocrinol (Lausanne) 9:376
Morselli, Lisa L; Temple, Karla A; Leproult, Rachel et al. (2018) Determinants of Slow-Wave Activity in Overweight and Obese Adults: Roles of Sex, Obstructive Sleep Apnea and Testosterone Levels. Front Endocrinol (Lausanne) 9:377
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Guyon, Aurore; Morselli, Lisa L; Balbo, Marcella L et al. (2017) Effects of Insufficient Sleep on Pituitary-Adrenocortical Response to CRH Stimulation in Healthy Men. Sleep 40:
Baron, Kelly Glazer; Reid, Kathryn J; Malkani, Roneil G et al. (2017) Sleep Variability Among Older Adults With Insomnia: Associations With Sleep Quality and Cardiometabolic Disease Risk. Behav Sleep Med 15:144-157
Peek, Clara Bien; Levine, Daniel C; Cedernaes, Jonathan et al. (2017) Circadian Clock Interaction with HIF1? Mediates Oxygenic Metabolism and Anaerobic Glycolysis in Skeletal Muscle. Cell Metab 25:86-92
Mokhlesi, Babak; Grimaldi, Daniela; Beccuti, Guglielmo et al. (2017) Effect of one week of CPAP treatment of obstructive sleep apnoea on 24-hour profiles of glucose, insulin and counter-regulatory hormones in type 2 diabetes. Diabetes Obes Metab 19:452-456
Jiang, Peng; Turek, Fred W (2017) Timing of meals: when is as critical as what and how much. Am J Physiol Endocrinol Metab 312:E369-E380

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