The over-arching goal of Core B is to assure optimal health and care of PPG animals to allow the Specific Aims of all projects to be achieved. Core B is a central element of this PPG as it is responsible for all aspects of the animal resource, specimen acquisition, performance of health assessments as well as collection of data for entry into the DR and aging database. To meet these goals, Core B has seven Specific Aims: 1. Provide daily care including veterinary and medical treatment as needed to assure health and well-being of all PPG animals. In this regard, Core B clearly defines study procedures that each animal will undergo. 2. Maintain nutritionally defined treatment groups. Our diets and indications for food allotment adjustments are clearly indicated. 3. Collect and dispense samples to the appropriate project of laboratory. 4. Conduct regular health assessments. 5. Coordinate transition from data collection to data entry. 6. Perform complete gross and microscopic study postmortem to document disease and cause of death, and procure and store tissues for future studies. Documentation of disease status and cause of death will be crucial to PPG long term goals. This requires thorough gross and microscopic evaluation. 7. Foster communication with the NIA calorie restriction group to explore potential areas of data sharing, and discuss disease and treatment issues.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Wisconsin Madison
United States
Zip Code
Maegawa, Shinji; Lu, Yue; Tahara, Tomomitsu et al. (2017) Caloric restriction delays age-related methylation drift. Nat Commun 8:539
Mattison, Julie A; Colman, Ricki J; Beasley, T Mark et al. (2017) Caloric restriction improves health and survival of rhesus monkeys. Nat Commun 8:14063
Polewski, Michael A; Burhans, Maggie S; Zhao, Minghui et al. (2015) Plasma diacylglycerol composition is a biomarker of metabolic syndrome onset in rhesus monkeys. J Lipid Res 56:1461-70
Fowler, Cynthia G; Chiasson, Kirstin Beach; Colman, Ricki J et al. (2015) Hyperinsulinemia/diabetes, hearing, and aging in the University of Wisconsin calorie restriction monkeys. Hear Res 328:78-86
Barger, Jamie L; Anderson, Rozalyn M; Newton, Michael A et al. (2015) A conserved transcriptional signature of delayed aging and reduced disease vulnerability is partially mediated by SIRT3. PLoS One 10:e0120738
Colman, Ricki J; Beasley, T Mark; Kemnitz, Joseph W et al. (2014) Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys. Nat Commun 5:3557
Sridharan, Aadhavi; Bendlin, Barbara B; Gallagher, Catherine L et al. (2014) Effect of age and calorie restriction on corpus callosal integrity in rhesus macaques: a fiber tractography study. Neurosci Lett 569:38-42
Pugh, Thomas D; Conklin, Matthew W; Evans, Trent D et al. (2013) A shift in energy metabolism anticipates the onset of sarcopenia in rhesus monkeys. Aging Cell 12:672-81
Willette, A A; Coe, C L; Birdsill, A C et al. (2013) Interleukin-8 and interleukin-10, brain volume and microstructure, and the influence of calorie restriction in old rhesus macaques. Age (Dordr) 35:2215-27
Csiszar, Anna; Sosnowska, Danuta; Tucsek, Zsuzsanna et al. (2013) Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells. J Gerontol A Biol Sci Med Sci 68:235-49

Showing the most recent 10 out of 120 publications