Abstract

The Hormone Core will provide established and state-of-the-art methods for measuring hormones and biochemical markers of bone turnover. These measurements will be done in the Mayo Foundation Immunochemical Core Laboratory (Mayo ICL), which is a specialized laboratory which provides dedicated immunochemical testing for both clinical and basic research through Mayo Foundation. The ICL laboratory provides the majority of the tests to support Mayo's General Clinical Research Center (GCRC). The availability of the expertise and equipment in the Hormone Core for the performance of the assays needed in this grant proposal is critical to the conduct of the proposed studies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG014383-02
Application #
6098737
Study Section
Project Start
1999-06-01
Project End
2000-05-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905

  Publications

Espinosa De Ycaza, Ana E; Rizza, Robert A; Nair, K Sreekumaran et al. (2016) Effect of Dehydroepiandrosterone and Testosterone Supplementation on Systemic Lipolysis. J Clin Endocrinol Metab 101:1719-28
Du, S; Rajjo, T; Santosa, S et al. (2014) The thermic effect of food is reduced in older adults. Horm Metab Res 46:365-9
Dalla Man, Chiara; Piccinini, Francesca; Basu, Rita et al. (2013) Modeling hepatic insulin sensitivity during a meal: validation against the euglycemic hyperinsulinemic clamp. Am J Physiol Endocrinol Metab 304:E819-25
Manesso, Erica; Toffolo, Gianna M; Basu, Rita et al. (2011) Modeling nonsteady-state metabolism from arteriovenous data. IEEE Trans Biomed Eng 58:1253-9
Koutsari, Christina; Ali, Asem H; Nair, K Sreekumaran et al. (2009) Fatty acid metabolism in the elderly: effects of dehydroepiandrosterone and testosterone replacement in hormonally deficient men and women. J Clin Endocrinol Metab 94:3414-23
Clarke, Bart L; Khosla, Sundeep (2009) New selective estrogen and androgen receptor modulators. Curr Opin Rheumatol 21:374-9
Man, Chiara Dalla; Toffolo, Gianna; Basu, Rita et al. (2008) Use of labeled oral minimal model to measure hepatic insulin sensitivity. Am J Physiol Endocrinol Metab 295:E1152-9
Dhatariya, Ketan K; Greenlund, Laura J S; Bigelow, Maureen L et al. (2008) Dehydroepiandrosterone replacement therapy in hypoadrenal women: protein anabolism and skeletal muscle function. Mayo Clin Proc 83:1218-25
Basu, Rita; Dalla Man, Chiara; Campioni, Marco et al. (2007) Two years of treatment with dehydroepiandrosterone does not improve insulin secretion, insulin action, or postprandial glucose turnover in elderly men or women. Diabetes 56:753-66
Cobelli, Claudio; Toffolo, Gianna Maria; Dalla Man, Chiara et al. (2007) Assessment of beta-cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous and oral glucose tests. Am J Physiol Endocrinol Metab 293:E1-E15

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