Abstract

They Body Composition/Exercise Core will provide comprehensive body composition analysis together with the exercise testing components of this grant proposal. Dual energy x-ray absorptiometry will be used to measure bone mineral density, fat free mass, and regional fat mass. CT scanning will be used to quantitate visceral adipose tissue mass and skeletal muscle area in the thigh. Total body water (2/H20) and extracellular fluid space (bromide space technique) will be measured to assess the quality of fat free mass as determined by dual energy x-ray absorptiometry. This core will also perform measurements of peak oxygen uptake, isotonic and isometric strength. In addition, this core will provide support for the large number of indirect calorimetry measurements which will be required for Protocols I, III, and IV. This core has access to state-of-the-art instruments for body composition analysis together high quality strength testing facilities. The availability of both the equipment and the expertise to conduct the body composition and exercise portions of this grant proposal assures high quality testing of the participants in this study.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG014383-03
Application #
6340638
Study Section
Project Start
2000-08-15
Project End
2001-05-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
3
Fiscal Year
2000
Total Cost
$228,564
Indirect Cost

  Institution

Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905

  Publications

Espinosa De Ycaza, Ana E; Rizza, Robert A; Nair, K Sreekumaran et al. (2016) Effect of Dehydroepiandrosterone and Testosterone Supplementation on Systemic Lipolysis. J Clin Endocrinol Metab 101:1719-28
Du, S; Rajjo, T; Santosa, S et al. (2014) The thermic effect of food is reduced in older adults. Horm Metab Res 46:365-9
Dalla Man, Chiara; Piccinini, Francesca; Basu, Rita et al. (2013) Modeling hepatic insulin sensitivity during a meal: validation against the euglycemic hyperinsulinemic clamp. Am J Physiol Endocrinol Metab 304:E819-25
Manesso, Erica; Toffolo, Gianna M; Basu, Rita et al. (2011) Modeling nonsteady-state metabolism from arteriovenous data. IEEE Trans Biomed Eng 58:1253-9
Koutsari, Christina; Ali, Asem H; Nair, K Sreekumaran et al. (2009) Fatty acid metabolism in the elderly: effects of dehydroepiandrosterone and testosterone replacement in hormonally deficient men and women. J Clin Endocrinol Metab 94:3414-23
Clarke, Bart L; Khosla, Sundeep (2009) New selective estrogen and androgen receptor modulators. Curr Opin Rheumatol 21:374-9
Man, Chiara Dalla; Toffolo, Gianna; Basu, Rita et al. (2008) Use of labeled oral minimal model to measure hepatic insulin sensitivity. Am J Physiol Endocrinol Metab 295:E1152-9
Dhatariya, Ketan K; Greenlund, Laura J S; Bigelow, Maureen L et al. (2008) Dehydroepiandrosterone replacement therapy in hypoadrenal women: protein anabolism and skeletal muscle function. Mayo Clin Proc 83:1218-25
Basu, Rita; Dalla Man, Chiara; Campioni, Marco et al. (2007) Two years of treatment with dehydroepiandrosterone does not improve insulin secretion, insulin action, or postprandial glucose turnover in elderly men or women. Diabetes 56:753-66
Cobelli, Claudio; Toffolo, Gianna Maria; Dalla Man, Chiara et al. (2007) Assessment of beta-cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous and oral glucose tests. Am J Physiol Endocrinol Metab 293:E1-E15

Showing the most recent 10 out of 20 publications