Abstract

We have a state-of-the-art mass spectrometry with highly trained technical staff. Several methodologies described in this proposal have been developed within our laboratory. The laboratory hs continuously making technical advances in terms of state-of-the-art equipment and development of novel and innovative techniques. Currently, the facility is supported in part by an NIH grants through the GCRC and Obesity Nutrition Research Center and the center of the support comes from various Foundation grants which the Principal Investigator has obtained through the Mayo Development Department. All of the technological developments initiated by the current technical staff will continue but the current commitments do not allow them to undertake any additional work. Most of the analysis involved in this study are highly time consuming and the time necessary from two additional technicians is essential for the time completion of all analyses. This Core also will provide support to the investigators in interpreting stable isotope data and bringing them up-to-date on new developments in the field.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG014383-05
Application #
6600405
Study Section
Project Start
2002-06-15
Project End
2003-05-31
Budget Start
Budget End
Support Year
5
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905

  Publications

Espinosa De Ycaza, Ana E; Rizza, Robert A; Nair, K Sreekumaran et al. (2016) Effect of Dehydroepiandrosterone and Testosterone Supplementation on Systemic Lipolysis. J Clin Endocrinol Metab 101:1719-28
Du, S; Rajjo, T; Santosa, S et al. (2014) The thermic effect of food is reduced in older adults. Horm Metab Res 46:365-9
Dalla Man, Chiara; Piccinini, Francesca; Basu, Rita et al. (2013) Modeling hepatic insulin sensitivity during a meal: validation against the euglycemic hyperinsulinemic clamp. Am J Physiol Endocrinol Metab 304:E819-25
Manesso, Erica; Toffolo, Gianna M; Basu, Rita et al. (2011) Modeling nonsteady-state metabolism from arteriovenous data. IEEE Trans Biomed Eng 58:1253-9
Koutsari, Christina; Ali, Asem H; Nair, K Sreekumaran et al. (2009) Fatty acid metabolism in the elderly: effects of dehydroepiandrosterone and testosterone replacement in hormonally deficient men and women. J Clin Endocrinol Metab 94:3414-23
Clarke, Bart L; Khosla, Sundeep (2009) New selective estrogen and androgen receptor modulators. Curr Opin Rheumatol 21:374-9
Man, Chiara Dalla; Toffolo, Gianna; Basu, Rita et al. (2008) Use of labeled oral minimal model to measure hepatic insulin sensitivity. Am J Physiol Endocrinol Metab 295:E1152-9
Dhatariya, Ketan K; Greenlund, Laura J S; Bigelow, Maureen L et al. (2008) Dehydroepiandrosterone replacement therapy in hypoadrenal women: protein anabolism and skeletal muscle function. Mayo Clin Proc 83:1218-25
Basu, Rita; Dalla Man, Chiara; Campioni, Marco et al. (2007) Two years of treatment with dehydroepiandrosterone does not improve insulin secretion, insulin action, or postprandial glucose turnover in elderly men or women. Diabetes 56:753-66
Cobelli, Claudio; Toffolo, Gianna Maria; Dalla Man, Chiara et al. (2007) Assessment of beta-cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous and oral glucose tests. Am J Physiol Endocrinol Metab 293:E1-E15

Showing the most recent 10 out of 20 publications