The proposed Statistic and Data Management Core for the Program Project will provide the computational and analytic resources for successful data collection, storage, linkage, and analysis for all the projects in the Program Project. The proposed core will have both a data management component and a statistical analysis component. The goals of the data management protion of the core include: 1) development of direct computer entry programs for the neuropathobiology data, 2) facilitation of transmission of computer- generated laboratory results, and 3) establishment and maintenance of a data base library linking all projects. The statistical responsibilities of the core will include providing design advice and statistical programming, and providing methodologic expertise on specific questions arising from the use of longitudinal studies with multiple measures of cognitive impairment. The research goals of this Program Project present complexities and challenges both in the management and in the analysis of the data. First, data management will be complicated because of the large quantity of data in varied formats from separate sites, the longitudinal nature of the styd designs and the need to link data from multiple times of observation and multiple studies within the core. The analysis of longitudinal data requires sophisticated methodology to characterize patterns of change in each person, to model similarities and differences across groups of people, and to look for associations between change in one measure and change in another or between clinical change and post-mortem neuropathobiologic findings. This core will provide expert support from a statistical research team experienced in the conduct of longitudinal studies.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
1P01AG014449-02
Application #
6267726
Study Section
Project Start
1998-07-01
Project End
1999-03-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Rush University Medical Center
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60612
Peng, Katherine Y; Pérez-González, Rocío; Alldred, Melissa J et al. (2018) Apolipoprotein E4 genotype compromises brain exosome production. Brain :
Ginsberg, Stephen D; Alldred, Melissa J; Gunnam, Satya M et al. (2018) Expression profiling suggests microglial impairment in human immunodeficiency virus neuropathogenesis. Ann Neurol 83:406-417
Tiernan, Chelsea T; Ginsberg, Stephen D; He, Bin et al. (2018) Pretangle pathology within cholinergic nucleus basalis neurons coincides with neurotrophic and neurotransmitter receptor gene dysregulation during the progression of Alzheimer's disease. Neurobiol Dis 117:125-136
Kaur, Gurjinder; Gauthier, Sebastien A; Perez-Gonzalez, Rocio et al. (2018) Cystatin C prevents neuronal loss and behavioral deficits via the endosomal pathway in a mouse model of down syndrome. Neurobiol Dis 120:165-173
Jansen, Willemijn J; Wilson, Robert S; Visser, Pieter Jelle et al. (2018) Age and the association of dementia-related pathology with trajectories of cognitive decline. Neurobiol Aging 61:138-145
Tiernan, Chelsea T; Mufson, Elliott J; Kanaan, Nicholas M et al. (2018) Tau Oligomer Pathology in Nucleus Basalis Neurons During the Progression of Alzheimer Disease. J Neuropathol Exp Neurol 77:246-259
Krivinko, Josh M; Erickson, Susan L; Ding, Ying et al. (2018) Synaptic Proteome Compensation and Resilience to Psychosis in Alzheimer's Disease. Am J Psychiatry 175:999-1009
Malek-Ahmadi, Michael; Chen, Kewei; Perez, Sylvia E et al. (2018) Cognitive composite score association with Alzheimer's disease plaque and tangle pathology. Alzheimers Res Ther 10:90
Edler, Melissa K; Sherwood, Chet C; Meindl, Richard S et al. (2018) Microglia changes associated to Alzheimer's disease pathology in aged chimpanzees. J Comp Neurol 526:2921-2936
Mahady, Laura; Nadeem, Muhammad; Malek-Ahmadi, Michael et al. (2018) Frontal Cortex Epigenetic Dysregulation During the Progression of Alzheimer's Disease. J Alzheimers Dis 62:115-131

Showing the most recent 10 out of 293 publications