Abstract

application): The core supports the scientific research effort of all 3 projects of the program by stocking mice of different ages in laminar flow facility developed at CUMC 10 years ago and maintaining genetic strains until they grow to the desired age. In addition the core makes available to project investigators specialized research techniques, organizes monthly meeting of the project investigators and yearly meetings with an outside group of scientific advisors.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
1P01AG014669-01A1
Application #
6267737
Study Section
Project Start
1998-07-01
Project End
1999-06-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Weill Medical College of Cornell University
Department
Type
DUNS #
201373169
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Szabo, Paul; Shen, Steven; Telford, William et al. (2003) Impaired rearrangement of IgH V to DJ segments in bone marrow Pro-B cells from old mice. Cell Immunol 222:78-87
Posnett, David N; Yarilin, Dmitry; Valiando, Jennifer R et al. (2003) Oligoclonal expansions of antigen-specific CD8+ T cells in aged mice. Ann N Y Acad Sci 987:274-9
Weksler, Marc E; Goodhardt, Michele; Szabo, Paul (2002) The effect of age on B cell development and humoral immunity. Springer Semin Immunopathol 24:35-52
Weksler, Marc E; Relkin, Norman; Turkenich, Rimma et al. (2002) Patients with Alzheimer disease have lower levels of serum anti-amyloid peptide antibodies than healthy elderly individuals. Exp Gerontol 37:943-8
Komers, R; Anderson, S; Epstein, M (2001) Renal and cardiovascular effects of selective cyclooxygenase-2 inhibitors. Am J Kidney Dis 38:1145-57
Radu, D L; Weksler, M E; Bona, C A (2001) Maintenance of size and function of influenza virus hemagglutinin specific transgenic T-cell clone during life. J Cell Mol Med 5:388-96
Li, F; Jin, F; Freitas, A et al. (2001) Impaired regeneration of the peripheral B cell repertoire from bone marrow following lymphopenia in old mice. Eur J Immunol 31:500-5
Weksler, M E (2000) Changes in the B-cell repertoire with age. Vaccine 18:1624-8
Weksler, M E; Szabo, P (2000) The effect of age on the B-cell repertoire. J Clin Immunol 20:240-9
LeMaoult, J; Messaoudi, I; Manavalan, J S et al. (2000) Age-related dysregulation in CD8 T cell homeostasis: kinetics of a diversity loss. J Immunol 165:2367-73

Showing the most recent 10 out of 16 publications