Abstract

This project will assess a variety of biomarkers of age in mice from the domains of behavior and physiology at approximately 150, 450, and 750 days of age. These measures have been selected on the basis and demonstrated age-relevance and genetic influence in addition to meeting standards of biometric adequacy and minimal stress. Most of the measures were employed in a previous research program on the quantitative genetics of aging biomarkers, which provides a valuable interpretational context for the new results on specific quantitative genetics of aging biomarkers, which provides a valuable interpretational context for the new results on specific quantitative trait loci (QTLs). Included are measures of strength and coordination, activity, urine osmolality, blood pressure, and several clinical blood measures. The animals to be employed are of two genetically defined groups: BXD recombinant inbred (RI) strains derived from C57BL/6 and DBA/2 inbred strain and F2 animals derived from the same progenitors. Each group has particular advantages and limitations in the multiple-stage approach to QTL identification and verification, and together offer an advantageous strategy for identifying true QTLs and eliminating from consideration false-positive indications.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG014731-02
Application #
6299395
Study Section
Project Start
2000-03-01
Project End
2001-01-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
2
Fiscal Year
2000
Total Cost
$353,404
Indirect Cost

  Institution

Name
Pennsylvania State University
Department
Type
DUNS #
City
University Park
State
PA
Country
United States
Zip Code
16802

  Publications

Sandri, M; Barberi, L; Bijlsma, A Y et al. (2013) Signalling pathways regulating muscle mass in ageing skeletal muscle: the role of the IGF1-Akt-mTOR-FoxO pathway. Biogerontology 14:303-23
Ramamurthy, B; Larsson, L (2013) Detection of an aging-related increase in advanced glycation end products in fast- and slow-twitch skeletal muscles in the rat. Biogerontology 14:293-301
Sloane, Lauren B; Stout, Joseph T; Austad, Steven N et al. (2011) Tail tendon break time: a biomarker of aging? J Gerontol A Biol Sci Med Sci 66:287-94
Sloane, Lauren B; Stout, Joseph T; Vandenbergh, David J et al. (2011) Quantitative trait loci analysis of tail tendon break time in mice of C57BL/6J and DBA/2J lineage. J Gerontol A Biol Sci Med Sci 66:170-8
Lionikas, Arimantas; Carlborg, Orjan; Lu, Lu et al. (2010) Genomic analysis of variation in hindlimb musculature of mice from the C57BL/6J and DBA/2J lineage. J Hered 101:360-7
Lang, Dean H; Conroy, David E; Lionikas, Arimantas et al. (2009) Bone, muscle, and physical activity: structural equation modeling of relationships and genetic influence with age. J Bone Miner Res 24:1608-17
Blizard, David A; Lionikas, Arimantas; Vandenbergh, David J et al. (2009) Blood pressure and heart rate QTL in mice of the B6/D2 lineage: sex differences and environmental influences. Physiol Genomics 36:158-66
Foreman, J E; Lionikas, A; Lang, D H et al. (2009) Genetic architecture for hole-board behaviors across substantial time intervals in young, middle-aged and old mice. Genes Brain Behav 8:714-27
Norman, Holly; Zackrisson, Håkan; Hedström, Yvette et al. (2009) Myofibrillar protein and gene expression in acute quadriplegic myopathy. J Neurol Sci 285:28-38
Cristea, A; Korhonen, M T; Hakkinen, K et al. (2008) Effects of combined strength and sprint training on regulation of muscle contraction at the whole-muscle and single-fibre levels in elite master sprinters. Acta Physiol (Oxf) 193:275-89

Showing the most recent 10 out of 48 publications