Abstract

The broad objective of this program project proposal is to maintain two different groups of genetically defined mice under highly controlled laboratory conditions and assess cross-sectional samples of these mice on a variety of age-related behavioral, immunological, physiological, neurobiological, and pathological processes at three ages, representing young adulthood, midlife and old age. Longevity will be determined in a separate group. These animals-recombinant inbred (RI) strains derived from the C57BL/6 and DBA/2 inbred strains and an F2 generation derived from these same progenitor strains-- are complementary elements in a two-phase program of identify chromosomal locations of genes (""""""""quantitative trait loci"""""""" or QTLs) that influence complex age-related traits. The localization of such QTLs will open up valuable research approaches both to the reductionist explorations of the mechanisms of aging processes, and also the integrative science relating interactions among genes and between genes and environmental factors in influencing the phenomena of aging.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG014731-03
Application #
6349727
Study Section
Special Emphasis Panel (ZAG1-PKN-2 (O3))
Program Officer
Mccormick, Anna M
Project Start
1999-02-01
Project End
2004-01-31
Budget Start
2001-05-01
Budget End
2002-01-31
Support Year
3
Fiscal Year
2001
Total Cost
$1,461,405
Indirect Cost

  Institution

Name
Pennsylvania State University
Department
Miscellaneous
Type
Schools of Allied Health Profes
DUNS #
City
University Park
State
PA
Country
United States
Zip Code
16802

  Publications

Sandri, M; Barberi, L; Bijlsma, A Y et al. (2013) Signalling pathways regulating muscle mass in ageing skeletal muscle: the role of the IGF1-Akt-mTOR-FoxO pathway. Biogerontology 14:303-23
Ramamurthy, B; Larsson, L (2013) Detection of an aging-related increase in advanced glycation end products in fast- and slow-twitch skeletal muscles in the rat. Biogerontology 14:293-301
Sloane, Lauren B; Stout, Joseph T; Austad, Steven N et al. (2011) Tail tendon break time: a biomarker of aging? J Gerontol A Biol Sci Med Sci 66:287-94
Sloane, Lauren B; Stout, Joseph T; Vandenbergh, David J et al. (2011) Quantitative trait loci analysis of tail tendon break time in mice of C57BL/6J and DBA/2J lineage. J Gerontol A Biol Sci Med Sci 66:170-8
Lionikas, Arimantas; Carlborg, Orjan; Lu, Lu et al. (2010) Genomic analysis of variation in hindlimb musculature of mice from the C57BL/6J and DBA/2J lineage. J Hered 101:360-7
Lang, Dean H; Conroy, David E; Lionikas, Arimantas et al. (2009) Bone, muscle, and physical activity: structural equation modeling of relationships and genetic influence with age. J Bone Miner Res 24:1608-17
Blizard, David A; Lionikas, Arimantas; Vandenbergh, David J et al. (2009) Blood pressure and heart rate QTL in mice of the B6/D2 lineage: sex differences and environmental influences. Physiol Genomics 36:158-66
Foreman, J E; Lionikas, A; Lang, D H et al. (2009) Genetic architecture for hole-board behaviors across substantial time intervals in young, middle-aged and old mice. Genes Brain Behav 8:714-27
Norman, Holly; Zackrisson, Håkan; Hedström, Yvette et al. (2009) Myofibrillar protein and gene expression in acute quadriplegic myopathy. J Neurol Sci 285:28-38
Cristea, A; Korhonen, M T; Hakkinen, K et al. (2008) Effects of combined strength and sprint training on regulation of muscle contraction at the whole-muscle and single-fibre levels in elite master sprinters. Acta Physiol (Oxf) 193:275-89

Showing the most recent 10 out of 48 publications