Abstract

The Animal Model Core will maintain breeding stock of C57/BL/6 and DBA/2 mice, of 22 BXD recombinant inbred (RI) strains derived initially from these strains, and of an F2 generation derived from the same strains. Mice will be produced from these stocks in sufficient number to meet the statistical requirements for cross-sectional biomarker assessment beginning at approximately 150, 450, or 750 days of age. An additional F2 group will be produced that will be maintained until natural death. All animals will be born, reared, and maintained in a specific-pathogen- free barrier facility. This Core will also serve as the common resource for the genotyping will also serve as the common resource for the genotyping of all of the subject animals for which genotyping is required, in order to provide the relevant data enabling the detection of quantitative trail loci (QTLs). The pathological analysis of all cross-sectional animals will also be the responsibility of this Core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG014731-03
Application #
6448903
Study Section
Project Start
2001-05-01
Project End
2002-01-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
3
Fiscal Year
2001
Total Cost
$157,506
Indirect Cost

  Institution

Name
Pennsylvania State University
Department
Type
DUNS #
City
University Park
State
PA
Country
United States
Zip Code
16802

  Publications

Sandri, M; Barberi, L; Bijlsma, A Y et al. (2013) Signalling pathways regulating muscle mass in ageing skeletal muscle: the role of the IGF1-Akt-mTOR-FoxO pathway. Biogerontology 14:303-23
Ramamurthy, B; Larsson, L (2013) Detection of an aging-related increase in advanced glycation end products in fast- and slow-twitch skeletal muscles in the rat. Biogerontology 14:293-301
Sloane, Lauren B; Stout, Joseph T; Austad, Steven N et al. (2011) Tail tendon break time: a biomarker of aging? J Gerontol A Biol Sci Med Sci 66:287-94
Sloane, Lauren B; Stout, Joseph T; Vandenbergh, David J et al. (2011) Quantitative trait loci analysis of tail tendon break time in mice of C57BL/6J and DBA/2J lineage. J Gerontol A Biol Sci Med Sci 66:170-8
Lionikas, Arimantas; Carlborg, Orjan; Lu, Lu et al. (2010) Genomic analysis of variation in hindlimb musculature of mice from the C57BL/6J and DBA/2J lineage. J Hered 101:360-7
Lang, Dean H; Conroy, David E; Lionikas, Arimantas et al. (2009) Bone, muscle, and physical activity: structural equation modeling of relationships and genetic influence with age. J Bone Miner Res 24:1608-17
Blizard, David A; Lionikas, Arimantas; Vandenbergh, David J et al. (2009) Blood pressure and heart rate QTL in mice of the B6/D2 lineage: sex differences and environmental influences. Physiol Genomics 36:158-66
Foreman, J E; Lionikas, A; Lang, D H et al. (2009) Genetic architecture for hole-board behaviors across substantial time intervals in young, middle-aged and old mice. Genes Brain Behav 8:714-27
Norman, Holly; Zackrisson, Håkan; Hedström, Yvette et al. (2009) Myofibrillar protein and gene expression in acute quadriplegic myopathy. J Neurol Sci 285:28-38
Cristea, A; Korhonen, M T; Hakkinen, K et al. (2008) Effects of combined strength and sprint training on regulation of muscle contraction at the whole-muscle and single-fibre levels in elite master sprinters. Acta Physiol (Oxf) 193:275-89

Showing the most recent 10 out of 48 publications