Abstract

Cognitive functions and brain cell activities show responses to estrogens that give a general basis for the protective effects of estrogen replacement therapy (ERT) in Alzheimer disease (AD). A team of USC investigators proposes experiments on rodent models in vivo and in vitro to analyze mechanisms by which estrogens interact with neurons and glia to modify synaptic plasticity. We will test the hypothesis that estrogens are neuroprotective by examining molecular, cellular, and physiological responses to estrogen and interactions with lesions in rats as a function of aging. We also examine bioactivities of equine estrogens that are constituents of Premarin, the most widely used ERT.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG014751-04
Application #
6168965
Study Section
Special Emphasis Panel (ZAG1-DAG-9 (M1))
Program Officer
Snyder, D Stephen
Project Start
1997-09-01
Project End
2002-07-31
Budget Start
2000-09-01
Budget End
2001-07-31
Support Year
4
Fiscal Year
2000
Total Cost
$946,115
Indirect Cost

  Institution

Name
University of Southern California
Department
Type
Organized Research Units
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Finch, Caleb E; Beltrán-Sánchez, Hiram; Crimmins, Eileen M (2014) Uneven futures of human lifespans: reckonings from Gompertz mortality rates, climate change, and air pollution. Gerontology 60:183-8
Baudry, M; Bi, X; Aguirre, C (2013) Progesterone-estrogen interactions in synaptic plasticity and neuroprotection. Neuroscience 239:280-94
Kim, Soyun; Wang, Miao; Lee, Amy S et al. (2011) Impaired eyeblink conditioning in 78 kDa-glucose regulated protein (GRP78)/immunoglobulin binding protein (BiP) conditional knockout mice. Behav Neurosci 125:404-11
Kim, Soyun; Thompson, Richard F (2011) c-Fos, Arc, and stargazin expression in rat eyeblink conditioning. Behav Neurosci 125:117-23
Dominguez, Reymundo; Hu, Eric; Zhou, Miou et al. (2009) 17beta-estradiol-mediated neuroprotection and ERK activation require a pertussis toxin-sensitive mechanism involving GRK2 and beta-arrestin-1. J Neurosci 29:4228-38
Thompson, Richard F (2009) Habituation: a history. Neurobiol Learn Mem 92:127-34
Micevych, Paul; Dominguez, Reymundo (2009) Membrane estradiol signaling in the brain. Front Neuroendocrinol 30:315-27
Brinton, Roberta Diaz (2009) Estrogen-induced plasticity from cells to circuits: predictions for cognitive function. Trends Pharmacol Sci 30:212-22
Wong, Angela M; Rozovsky, Irina; Arimoto, Jason M et al. (2009) Progesterone influence on neurite outgrowth involves microglia. Endocrinology 150:324-32
Lee, Ka Hung; Chatila, Talal A; Ram, Rana A et al. (2009) Impaired memory of eyeblink conditioning in CaMKIV KO mice. Behav Neurosci 123:438-42

Showing the most recent 10 out of 54 publications