Abstract

The animal core will provide program project investigators with access to aged rhesus macaques and support services for the projects of Drs. Morrison, Kordower and Rapp. A colony of forty aged female rhesus and thirty young control females will be maintained at the California National Primate Research Center for behavioral and neuroanatomical studies. Each animal's database will include daily determination of menses cycle activity, monitoring of reproductive hormone metabolites in the urine, serum hormone levels, and routine clinical parameters such as weights and complete blood counts. The animal core will perform bilateral ovariectomies on aged females and young controls, and chronic or acute hormone replacement with either estradiol and/or progesterone. The animal core will also provide animal handling and transport for behavioral studies. Macaque reproductive and physiological parameters will be easily accessible to all investigators for experimental analysis. The animal core will also provide complete necropsies on all animals. A tissue archive will be maintained and tissues will be distributed to other investigators interested in analyzing specific tissues with regard to aging and estrogen effects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
2P01AG016765-06A1
Application #
6869952
Study Section
Special Emphasis Panel (ZAG1-ZIJ-6 (O1))
Project Start
2005-03-15
Project End
2010-02-28
Budget Start
2005-03-15
Budget End
2006-02-28
Support Year
6
Fiscal Year
2005
Total Cost
$384,987
Indirect Cost

  Institution

Name
Mount Sinai School of Medicine
Department
Type
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

Baxter, Mark G; Santistevan, Anthony C; Bliss-Moreau, Eliza et al. (2018) Timing of cyclic estradiol treatment differentially affects cognition in aged female rhesus monkeys. Behav Neurosci 132:213-223
Crimins, Johanna L; Puri, Rishi; Calakos, Katina C et al. (2018) Synaptic distributions of pS214-tau in rhesus monkey prefrontal cortex are associated with spine density, but not with cognitive decline. J Comp Neurol :
Milham, Michael P; Ai, Lei; Koo, Bonhwang et al. (2018) An Open Resource for Non-human Primate Imaging. Neuron 100:61-74.e2
Motley, Sarah E; Grossman, Yael S; Janssen, William G M et al. (2018) Selective Loss of Thin Spines in Area 7a of the Primate Intraparietal Sulcus Predicts Age-Related Working Memory Impairment. J Neurosci 38:10467-10478
Bliss-Moreau, Eliza; Baxter, Mark G (2018) Estradiol treatment in a nonhuman primate model of menopause preserves affective reactivity. Behav Neurosci 132:224-229
Garcia, Alexandra N; Depena, Christina; Bezner, Kelsey et al. (2018) The timing and duration of estradiol treatment in a rat model of the perimenopause: Influences on social behavior and the neuromolecular phenotype. Horm Behav 97:75-84
Beckman, Danielle; Baxter, Mark G; Morrison, John H (2018) Future directions in animal models of Alzheimer's disease. J Neurosci Res 96:1829-1830
McEwen, Bruce S; Milner, Teresa A (2017) Understanding the broad influence of sex hormones and sex differences in the brain. J Neurosci Res 95:24-39
Nutsch, Victoria L; Bell, Margaret R; Will, Ryan G et al. (2017) Aging and estradiol effects on gene expression in the medial preoptic area, bed nucleus of the stria terminalis, and posterodorsal medial amygdala of male rats. Mol Cell Endocrinol 442:153-164
Garcia, Alexandra N; Bezner, Kelsey; Depena, Christina et al. (2017) The effects of long-term estradiol treatment on social behavior and gene expression in adult female rats. Horm Behav 87:145-154

Showing the most recent 10 out of 132 publications