? CORE A The overall goals of the Administrative Core of the Program Project Grant (PPG) are to provide general scientific, programmatic and fiscal leadership, facilitate lines of communication between the different researchers involved in the PPG, maintain coherence in the PPG's overall and long-range goals, coordinate data analysis and sharing, monitor human subjects issues and issues related to the use of vertebrate animals, and ensure that resources resulting from the PPG will benefit the scientific community. In the context of the above, the tasks of this Core include effective coordination of activities in the four Research Projects and the Bioinformatics Core to best achieve the overall goal of elucidating the mechanisms through which DNA damage drives important aspects of aging and age-related diseases and how certain genome maintenance genotypes found associated with extreme human longevity can preserve genome integrity over longer periods of time. Well-coordinated activities of the Projects and Cores will promote the mobilization of new human data sources and analysis techniques that will allow us to more specifically test the functional impact of DNA damage and its various end points, providing computational and statistical services to all members of the PPG as needed and providing access by the scientific community to the PPG's resources, information and technologies through the internet.

Public Health Relevance

? CORE A Core A will coordinate the research in this Program Project Grant (PPG), which has its members at different geographical locations. Through its Director, Dr. Jan Vijg, its Administrator, Ms. Stephanie Alfieri, and its Administrative Assistant, Ms. Yolanne Blake, Core A will organized the necessary teleconferences, meetings, exchange visits, etc., to hold this PPG together and create an atmosphere of collegiality, in which the focus is on collaboration, with results interpreted in an integrated manner across all research projects.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
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Special Emphasis Panel (ZAG1)
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Albert Einstein College of Medicine
United States
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Lau, Cia-Hin; Suh, Yousin (2018) In vivo epigenome editing and transcriptional modulation using CRISPR technology. Transgenic Res 27:489-509
Wiley, Christopher D; Schaum, Nicholas; Alimirah, Fatouma et al. (2018) Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype. Sci Rep 8:2410
Quispe-Tintaya, Wilber; Lee, Moonsook; Dong, Xiao et al. (2018) Bleomycin-induced genome structural variations in normal, non-tumor cells. Sci Rep 8:16523
H├ębert, Jean M; Vijg, Jan (2018) Cell Replacement to Reverse Brain Aging: Challenges, Pitfalls, and Opportunities. Trends Neurosci 41:267-279
Jeon, Ok Hee; Kim, Chaekyu; Laberge, Remi-Martin et al. (2017) Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment. Nat Med 23:775-781
Andriani, Grasiella A; Vijg, Jan; Montagna, Cristina (2017) Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain. Mech Ageing Dev 161:19-36
Vijg, Jan; Dong, Xiao; Milholland, Brandon et al. (2017) Genome instability: a conserved mechanism of ageing? Essays Biochem 61:305-315
Lau, Cia-Hin; Suh, Yousin (2017) Genome and Epigenome Editing in Mechanistic Studies of Human Aging and Aging-Related Disease. Gerontology 63:103-117
Lau, Cia-Hin; Suh, Yousin (2017) In vivo genome editing in animals using AAV-CRISPR system: applications to translational research of human disease. F1000Res 6:2153
Hernandez-Segura, Alejandra; de Jong, Tristan V; Melov, Simon et al. (2017) Unmasking Transcriptional Heterogeneity in Senescent Cells. Curr Biol 27:2652-2660.e4

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