The Biostatistics and Data Management Core (Core E) proposal here is part of a Program Project Grant (PPG) application to elucidate mechanisms of brain degeneration in hereditary and sporadic frontotemporal dementias (FTD) or frontotemporal lobar degeneration (FTLD). This core supports all data management, statistical, and computing needs, as well as maintains the PPG database for data from studies for all Cores and Projects 1-4 within this PPG. The provided services include: (a) support for data form design and development, database development and management, database audit trail, database security, database backup, and stringent data quality control procedures; (b) computing and programming support for all PPG activities, including implementation and integration of hardware and software upgrades necessary for data management and research, as well as routine and archival off-site backup of computing systems central to the PPG, including the PPG database; (c) biostatistical support for all study aspects from inception to publication, including development of study design, performing sample size and power calculations, and performing analyses of PPG data; and (d) development of new statistical methodologies where needed for data analysis. Thus, Core E plays an important and significant role that is critical to the progress of research and the conduct of studies in this PPG. The studies proposed in this Core taken together with the complementary studies conducted in the other 3 Cores and all 4 Projects in this PPG will lead to a better understanding of the neurodegenerative mechanisms underlying FTLD, especially FTLD-Tau, which is likely to enhance efforts to develop better diagnostics and therapeutic interventions for these disorders.
BIOSTATISTICS & DATA MANAGEMENT CORE: Project Narrative Core E provides database, computing, and biostatistical support to the research pursued in Projects 1-4 as well as for studies conducted in the Clinical Core (Core B), the Genetics Core (Core C), and the Neuropathology and Biomarker Core (Core D) as well as for collaborative studies conducted by PPG investigators at and beyond the University of Pennsylvania.
|Gibbons, Garrett S; Lee, Virginia M Y; Trojanowski, John Q (2018) Mechanisms of Cell-to-Cell Transmission of Pathological Tau: A Review. JAMA Neurol :|
|Bergeron, David; Gorno-Tempini, Maria L; Rabinovici, Gil D et al. (2018) Prevalence of amyloid-? pathology in distinct variants of primary progressive aphasia. Ann Neurol 84:729-740|
|Kovacs, Gabor G; Xie, Sharon X; Robinson, John L et al. (2018) Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain. Acta Neuropathol Commun 6:50|
|Martini-Stoica, Heidi; Cole, Allysa L; Swartzlander, Daniel B et al. (2018) TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading. J Exp Med 215:2355-2377|
|Nativio, Raffaella; Donahue, Greg; Berson, Amit et al. (2018) Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease. Nat Neurosci 21:497-505|
|Olm, Christopher A; McMillan, Corey T; Irwin, David J et al. (2018) Longitudinal structural gray matter and white matter MRI changes in presymptomatic progranulin mutation carriers. Neuroimage Clin 19:497-506|
|Portelius, Erik; Olsson, Bob; Höglund, Kina et al. (2018) Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology. Acta Neuropathol 136:363-376|
|Pottier, Cyril; Zhou, Xiaolai; Perkerson 3rd, Ralph B et al. (2018) Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study. Lancet Neurol 17:548-558|
|Irwin, David J; Xie, Sharon X; Coughlin, David et al. (2018) CSF tau and ?-amyloid predict cerebral synucleinopathy in autopsied Lewy body disorders. Neurology 90:e1038-e1046|
|Ferraro, Pilar M; Jester, Charles; Olm, Christopher A et al. (2018) Perfusion alterations converge with patterns of pathological spread in transactive response DNA-binding protein 43 proteinopathies. Neurobiol Aging 68:85-92|
Showing the most recent 10 out of 593 publications