Abstract

The primary goal is to support Projects 1, 2 and 3 by supplying precise and accurate measurements of markers of bone formation and bone resorption, serum levels of calcium-regulating hormones, and of structural variables in the upper femora. Bone formation will be assessed by serum osteocalcium and serum bone alkaline phosphatase. Bone resorption will be assessed by urinary n- telopeptide crosslinks. Calcium-regulating hormones will be assessed by serum parathyroid hormones, serum 25OH vitamin D, and serum 1,25(OH)2 vitamin D. Health and safety will be assessed by a hematological and biochemical screen and pregnancy tests. Bone structure at the hip will be measured from radiographs and from volumetric quantitative computed tomography scans. The core will also be responsible for ensuring: that all biological samples and radiological images arising from Projects 1, 2 and 3 are logged-in, processed and stored under optimal conditions; that assays and structural variables are performed with precision and accuracy; that the data generated are entered in appropriate databases and transferred in a timely fashion to the Administrative and Biostatistics Core (Core A) and the Informatics and Genetics Core (Core C) for analysis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
1P01AG018397-01
Application #
6399706
Study Section
Special Emphasis Panel (ZAG1)
Project Start
2000-09-30
Project End
2005-06-30
Budget Start
Budget End
Support Year
1
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202

  Publications

Robinson-Cohen, Cassianne; Bartz, Traci M; Lai, Dongbing et al. (2018) Genetic Variants Associated with Circulating Fibroblast Growth Factor 23. J Am Soc Nephrol 29:2583-2592
Zeng, Y; Zhang, L; Zhu, W et al. (2017) Network based subcellular proteomics in monocyte membrane revealed novel candidate genes involved in osteoporosis. Osteoporos Int 28:3033-3042
Koller, Daniel L; Imel, Erik A; Lai, Dongbing et al. (2016) Genome-wide association study of serum iron phenotypes in premenopausal women of European descent. Blood Cells Mol Dis 57:50-3
Pei, Yu-Fang; Tian, Qing; Zhang, Lei et al. (2016) Exploring the Major Sources and Extent of Heterogeneity in a Genome-Wide Association Meta-Analysis. Ann Hum Genet 80:113-22
Pei, Yu-Fang; Hu, Wen-Zhu; Hai, Rong et al. (2016) Genome-wide association meta-analyses identified 1q43 and 2q32.2 for hip Ward's triangle areal bone mineral density. Bone 91:1-10
Niu, Tianhua; Liu, Ning; Yu, Xun et al. (2016) Identification of IDUA and WNT16 Phosphorylation-Related Non-Synonymous Polymorphisms for Bone Mineral Density in Meta-Analyses of Genome-Wide Association Studies. J Bone Miner Res 31:358-68
Liu, Yao-Zhong; Zhou, Yu; Zhang, Lei et al. (2015) Attenuated monocyte apoptosis, a new mechanism for osteoporosis suggested by a transcriptome-wide expression study of monocytes. PLoS One 10:e0116792
Pei, Yu-Fang; Zhang, Lei; Liu, Yongjun et al. (2014) Meta-analysis of genome-wide association data identifies novel susceptibility loci for obesity. Hum Mol Genet 23:820-30
Zhang, Lei; Choi, Hyung Jin; Estrada, Karol et al. (2014) Multistage genome-wide association meta-analyses identified two new loci for bone mineral density. Hum Mol Genet 23:1923-33
Alam, Imranul; Padgett, Leah R; Ichikawa, Shoji et al. (2014) SIBLING family genes and bone mineral density: association and allele-specific expression in humans. Bone 64:166-72

Showing the most recent 10 out of 86 publications