Abstract

(from the application): This Core will serve as the Optical Imaging Core of the Program Project. Dr. Lechleiter will serve as the Leader. The Core will be responsible for the following functions in the Program Project: 1. To provide optical microscopic instrumentation for all of the principal investigators of the program project who require such instrumentation for the proposed studies. 2. To provide computer hardware and software for analysis of digital images and production of publication quality prints. 3. To write application-specific software, maintain our NT Server, and to provide computer application support and training related to the microscope image acquisition and analysis. 4. To provide consultation and education regarding the theory and application of optical imaging to the participants of this program project to insure the quality of research conducted by the Projects and Cores.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG019316-02
Application #
6649908
Study Section
Special Emphasis Panel (ZAG1)
Project Start
2002-09-01
Project End
2003-08-31
Budget Start
Budget End
Support Year
2
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of Texas Health Science Center San Antonio
Department
Type
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229

  Publications

Van Skike, Candice E; Jahrling, Jordan B; Olson, Angela B et al. (2018) Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment. Am J Physiol Heart Circ Physiol 314:H693-H703
Soteros, Breeanne M; Cong, Qifei; Palmer, Christian R et al. (2018) Sociability and synapse subtype-specific defects in mice lacking SRPX2, a language-associated gene. PLoS One 13:e0199399
Deng, Yilun; Qin, Yuejuan; Srikantan, Subramanya et al. (2018) The TMEM127 human tumor suppressor is a component of the mTORC1 lysosomal nutrient-sensing complex. Hum Mol Genet 27:1794-1808
Deng, Yilun; Flores, Shahida K; Cheng, ZiMing et al. (2017) Molecular and phenotypic evaluation of a novel germline TMEM127 mutation with an uncommon clinical presentation. Endocr Relat Cancer 24:L79-L82
Wu, Junjie; Sun, Yun; Block, Travis J et al. (2016) Umbilical cord blood-derived non-hematopoietic stem cells retrieved and expanded on bone marrow-derived extracellular matrix display pluripotent characteristics. Stem Cell Res Ther 7:176
Doiron, Bruno; Hu, Wenchao; DeFronzo, Ralph A (2016) Beta Cell Formation in vivo Through Cellular Networking, Integration and Processing (CNIP) in Wild Type Adult Mice. Curr Pharm Biotechnol 17:376-88
Solano Fonseca, Rene; Mahesula, Swetha; Apple, Deana M et al. (2016) Neurogenic Niche Microglia Undergo Positional Remodeling and Progressive Activation Contributing to Age-Associated Reductions in Neurogenesis. Stem Cells Dev 25:542-55
Callaway, Danielle A; Riquelme, Manuel A; Sharma, Ramaswamy et al. (2015) Caspase-2 modulates osteoclastogenesis through down-regulating oxidative stress. Bone 76:40-8
Lee, Hak Joo; Feliers, Denis; Mariappan, Meenalakshmi M et al. (2015) Tadalafil Integrates Nitric Oxide-Hydrogen Sulfide Signaling to Inhibit High Glucose-induced Matrix Protein Synthesis in Podocytes. J Biol Chem 290:12014-26
Choveau, Frank S; Zhang, Jie; Bierbower, Sonya M et al. (2015) The Role of the Carboxyl Terminus Helix C-D Linker in Regulating KCNQ3 K+ Current Amplitudes by Controlling Channel Trafficking. PLoS One 10:e0145367

Showing the most recent 10 out of 120 publications