The Clinical and Administrative Core provides essential operational functions for the entire PPG. This Corewill recruit patients with frontotemporal dementia (FTD), semantic dementia (SD), progressive non-fluentaphasia (PNFA), progressive supranuclear palsy (PSP), corticobasaldegeneration (CBD), amyotrophiclateral sclerosis (ALS), Alzheimer's disease (AD), and normal control subjects. Each subject will receive acomprehensive evaluation measuring a broad range of neurological, neuropsychological,functional,neurobehavioral, and social-personality variables. In addition, subjects will be followed annually to collectlongitudinal data and maintain high enrollment in our autopsy program. Administrative functions of this Coreinclude the infrastructure for establishing policies and procedures, maintaining communication within thePPG and between the PPG and the scientific community, ensuring optimal utilization and monitoring of PPGresources, and ensuring the scientific and ethical integrity of all PPG practices. Once recruited into theClinical and Administrative Core, subjects will be referred to Projects 2 (Imaging; Dr. Weiner), 3 (Emotion;Dr. Levenson), 4 (Clinical Diagnosis; Dr. Miller), and 5 (Brain-Behavior; Dr. Rosen). In addition, bloodsamples will be sent to the Genetics Core (Dr.Geschwind) and autopsy tissue will be sent to the PathologyCore (Drs. Trojanowski and Lee). The Clinical and Administrative Core will also interact extensively with theData Management and Biostatistics Core (Dr.Fox) for data management, data quality, and data analysisfunctions.
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