The performance of innovative research on Alzheimer and dementia and non-AD dementias in the context of brain aging increasinglyrequires synergisticinteractionsbetweenclinical branches of agiven study, pathologicalinformationand modern and sophisticatedgenetic analyses. Furthermore,a critical step in progress towards understandingthe pathophysiology (and thus ultimately treatment) of different forms of dementia is assessing how different genotypes contribute to variability in disease phenotype. This type of correlation is a preamble to the equally importantgoal of understandinggene-environment interactions. The UCLA Core for The Genetic Analysis of FTLD is an integrated, state-of-the art laboratory that studies the Genetics and Molecular Biology of Frontotemporal Dementia and related dementias. The Core leverages the clinical strengths of the UCSF Center for Memory and Aging and Alzheimer's Disease Research Center (ADRC), as well as the UCSF investigators' longitudinal studies of dementia that provides clinical material for research projects. To further understand FTLD genetics and establish more specific genetic markers of the disease the work of the core sets several Specific Aims which include: 1) collection and banking of DMA on subjects with FTLD, AD and control subjects; 2) genotyping for known genetic risk factors (e.g. ApoE, Tau, Prion protein and PS-1); 3) exploratory investigation of RNA expression profiles for biomarker discovery and patient classification using microarray technology, and 4) development of interdisciplinary collaborations and research training. The fundamental purpose of this core is service, and the data obtained will be highly supportive and useful for other ongoing hypothesis driven projects in the PPG. The Genetic Core will also provide genetic screening and will perform genotyping studies of familial FTLD and AD. These core services build upon the laboratory's expertise derived from previous and ongoing, synergistic, genetic projects involving assessment of genetic risk factors and neurobehavioral phenotypes in FTLD, sequencing of genes related to tau to identify novel genetic risk factors for FTLD and AD, functional genomic based biomarker discovery and microarray based profiling of individuals for peripheral biomarkers using peripheral tissues and established cell lines. In this way, the core provides the necessary genetic foundation for the PPG by leveraging existing expertise and resources, thus delivering its services in the most efficient manner.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG019724-07
Application #
7676832
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2008-09-01
Budget End
2009-08-31
Support Year
7
Fiscal Year
2008
Total Cost
$144,030
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Ljubenkov, Peter A; Staffaroni, Adam M; Rojas, Julio C et al. (2018) Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory. Ann Clin Transl Neurol 5:1250-1263
La Joie, Renaud; Bejanin, Alexandre; Fagan, Anne M et al. (2018) Associations between [18F]AV1451 tau PET and CSF measures of tau pathology in a clinical sample. Neurology 90:e282-e290
Kim, Eun-Joo; Brown, Jesse A; Deng, Jersey et al. (2018) Mixed TDP-43 proteinopathy and tauopathy in frontotemporal lobar degeneration: nine case series. J Neurol 265:2960-2971
Henry, Maya L; Hubbard, H Isabel; Grasso, Stephanie M et al. (2018) Retraining speech production and fluency in non-fluent/agrammatic primary progressive aphasia. Brain 141:1799-1814
Nana, Alissa L; Sidhu, Manu; Gaus, Stephanie E et al. (2018) Neurons selectively targeted in frontotemporal dementia reveal early stage TDP-43 pathobiology. Acta Neuropathol :
Vatsavayai, Sarat C; Nana, Alissa L; Yokoyama, Jennifer S et al. (2018) C9orf72-FTD/ALS pathogenesis: evidence from human neuropathological studies. Acta Neuropathol :
Ossenkoppele, Rik; Rabinovici, Gil D; Smith, Ruben et al. (2018) Discriminative Accuracy of [18F]flortaucipir Positron Emission Tomography for Alzheimer Disease vs Other Neurodegenerative Disorders. JAMA 320:1151-1162
Mandelli, Maria Luisa; Welch, Ariane E; Vilaplana, Eduard et al. (2018) Altered topology of the functional speech production network in non-fluent/agrammatic variant of PPA. Cortex 108:252-264
Pressman, Peter S; Shdo, Suzanne; Simpson, Michaela et al. (2018) Neuroanatomy of Shared Conversational Laughter in Neurodegenerative Disease. Front Neurol 9:464
Caverzasi, Eduardo; Mandelli, Maria Luisa; Hoeft, Fumiko et al. (2018) Abnormal age-related cortical folding and neurite morphology in children with developmental dyslexia. Neuroimage Clin 18:814-821

Showing the most recent 10 out of 607 publications