Abstract

This is a clinical support core.
The Aims are:
Aim 1. To provide basic administrative support for the operation of the entire Project.
Aim 2 : To provide basic statistical support for all of the Projects.
Aim 3. To screen subjects for the clinical and brain bank components of the Program Project.
Aim 4. To recruit subjects for clinical projects.
Aim 5. To provide technical and interpretive support for tests and procedures that are preformed in Projects #1 and #2.
Aim 6 : To provide clinical and research database management.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG021190-03
Application #
7260481
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2006-06-01
Budget End
2007-05-31
Support Year
3
Fiscal Year
2006
Total Cost
$201,163
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Connor, James R; Patton, Stephanie M; Oexle, Konrad et al. (2017) Iron and restless legs syndrome: treatment, genetics and pathophysiology. Sleep Med 31:61-70
Allen, Richard P; Donelson, Nathan C; Jones, Byron C et al. (2017) Animal models of RLS phenotypes. Sleep Med 31:23-28
Skeba, Patrick; Hiranniramol, Kasidet; Earley, Christopher J et al. (2016) Inter-movement interval as a primary stable measure of periodic limb movements of sleep. Sleep Med 17:138-43
Allen, Richard P (2015) Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology. Sleep Med Clin 10:207-14, xi
Unger, Erica L; Bianco, Laura E; Jones, Byron C et al. (2014) Low brain iron effects and reversibility on striatal dopamine dynamics. Exp Neurol 261:462-8
Unger, E L; Jones, B C; Bianco, L E et al. (2014) Diurnal variations in brain iron concentrations in BXD RI mice. Neuroscience 263:54-9
Jellen, L C; Lu, L; Wang, X et al. (2013) Iron deficiency alters expression of dopamine-related genes in the ventral midbrain in mice. Neuroscience 252:13-23
Earley, Christopher J; Kuwabara, Hiroto; Wong, Dean F et al. (2013) Increased synaptic dopamine in the putamen in restless legs syndrome. Sleep 36:51-7
Unger, E L; Earley, C J; Thomsen, L L et al. (2013) Effects of IV iron isomaltoside-1000 treatment on regional brain iron status in an iron-deficient animal. Neuroscience 246:179-85
Allen, Richard P; Barker, Peter B; Horská, Alena et al. (2013) Thalamic glutamate/glutamine in restless legs syndrome: increased and related to disturbed sleep. Neurology 80:2028-34

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