The major goal of this proposal is to use genetically defined animals to show how iron content in the brain is related to iron parameters in the periphery. The animal model to be employed in this research consists of a panel of recombinant inbred (RI) mouse strains, to refine the natural traits relating to high- and low-brain iron concentration. The mandate of this Core is to provide animals with phenotypic characteristics relating to brain iron concentration.
Aim 1. To provide animals, animal tissue and support service for Projects #3 and #4.
Aim 2. To maintain a colony of BXD inbred mice in order to refine the current phenotype or to explore other phenotypic characteristics that are identified in RLS subjects or autopsy material over the ensuing years of the Program Project.
Aim 3. To perform quantitative genetic analysis on nigral brain iron content.
| Connor, James R; Patton, Stephanie M; Oexle, Konrad et al. (2017) Iron and restless legs syndrome: treatment, genetics and pathophysiology. Sleep Med 31:61-70 |
| Allen, Richard P; Donelson, Nathan C; Jones, Byron C et al. (2017) Animal models of RLS phenotypes. Sleep Med 31:23-28 |
| Skeba, Patrick; Hiranniramol, Kasidet; Earley, Christopher J et al. (2016) Inter-movement interval as a primary stable measure of periodic limb movements of sleep. Sleep Med 17:138-43 |
| Allen, Richard P (2015) Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology. Sleep Med Clin 10:207-14, xi |
| Unger, Erica L; Bianco, Laura E; Jones, Byron C et al. (2014) Low brain iron effects and reversibility on striatal dopamine dynamics. Exp Neurol 261:462-8 |
| Unger, E L; Jones, B C; Bianco, L E et al. (2014) Diurnal variations in brain iron concentrations in BXD RI mice. Neuroscience 263:54-9 |
| Unger, E L; Earley, C J; Thomsen, L L et al. (2013) Effects of IV iron isomaltoside-1000 treatment on regional brain iron status in an iron-deficient animal. Neuroscience 246:179-85 |
| Allen, Richard P; Barker, Peter B; Horská, Alena et al. (2013) Thalamic glutamate/glutamine in restless legs syndrome: increased and related to disturbed sleep. Neurology 80:2028-34 |
| Jellen, L C; Lu, L; Wang, X et al. (2013) Iron deficiency alters expression of dopamine-related genes in the ventral midbrain in mice. Neuroscience 252:13-23 |
| Earley, Christopher J; Kuwabara, Hiroto; Wong, Dean F et al. (2013) Increased synaptic dopamine in the putamen in restless legs syndrome. Sleep 36:51-7 |
Showing the most recent 10 out of 50 publications
