Episodic memory is defined as memory for personally experienced events bound in unique space/time contexts. Independent living and quality of life are related to the maintenance of episodic memory. Thus, episodic memory in late life is an important research focus.
The first aim of this project is to examine age differences in objective measures of memory and provide new evidence on the pictorial superiority effect as an episodic memory phenomenon in the oldest-old.
The second aim i s to examine the contribution of individual ability differences to episodic memory performance. The proposed individual difference variables include: a) general intellectual abilities, b) demographic characteristics, c) cognitive and affective status, and d) knowledge of memory aging.
The third aim i s to examine subjective memory appraisal in adulthood using self-report measures of memory functioning in everyday life.
The fourth aim i s to provide new evidence on the psychometric properties of the practical memory concerns in adulthood survey and examine relationships among our assessments of self-reported memory ability and objective memory performance. The fifth aim is to implement a pilot intervention to test the hypothesis that memory for everyday activities in daily life can be improved by providing illustrative pictures of the to-be-performed tasks during acquisition. In addition, we will examine relationships among measures of cognitive function and the genetic, metabolic, and physical functional outcome measures included in this proposal. Specifically, we will explore hypothesized relationships between APOE *4 (Project 1), vascular status and physical function (Project 4), and cognitive function (this Project). We also anticipate that relationships may exist between resting metabolic rate and total daily energy expenditure (Project 3) and self-reported health, social activity/lifestyle characteristics, and affective status (this Project). The multidisciplinary approach in this proposal permits a unique opportunity for assessment across multiple domains of functioning, which is essential for evolving a more complete understanding of age-related changes in cognitive status and memory functioning in very old age. Given the increased prevalence of cardiovascular disease and other chronic health conditions that adversely affect cognitive functioning in very old age, we anticipate that the present research will lead to the development of multidimensional criteria to define """"""""healthy aging"""""""" in late life.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG022064-03
Application #
7262447
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2006-07-15
Budget End
2007-06-30
Support Year
3
Fiscal Year
2006
Total Cost
$86,899
Indirect Cost
Name
Louisiana State University Hsc New Orleans
Department
Type
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112
Kim, Sangkyu; Jazwinski, S Michal (2018) The Gut Microbiota and Healthy Aging: A Mini-Review. Gerontology 64:513-520
Jazwinski, S Michal; Jiang, James C; Kim, Sangkyu (2018) Adaptation to metabolic dysfunction during aging: Making the best of a bad situation. Exp Gerontol 107:87-90
Maffei, Vincent J; Kim, Sangkyu; Blanchard 4th, Eugene et al. (2017) Biological Aging and the Human Gut Microbiota. J Gerontol A Biol Sci Med Sci 72:1474-1482
Kim, Sangkyu; Myers, Leann; Wyckoff, Jennifer et al. (2017) The frailty index outperforms DNA methylation age and its derivatives as an indicator of biological age. Geroscience 39:83-92
Cherry, Katie E; Brown, Jennifer Silva; Kim, Sangkyu et al. (2016) Social Factors and Healthy Aging: Findings from the Louisiana Healthy Aging Study (LHAS). Kinesiol Rev (Champaign) 5:50-56
Kim, Sangkyu; Myers, Leann; Ravussin, Eric et al. (2016) Single nucleotide polymorphisms linked to mitochondrial uncoupling protein genes UCP2 and UCP3 affect mitochondrial metabolism and healthy aging in female nonagenarians. Biogerontology 17:725-36
Kim, Sangkyu; Simon, Eric; Myers, Leann et al. (2016) Programmed Cell Death Genes Are Linked to Elevated Creatine Kinase Levels in Unhealthy Male Nonagenarians. Gerontology 62:519-29
Kim, Sangkyu; Welsh, David A; Myers, Leann et al. (2015) Non-coding genomic regions possessing enhancer and silencer potential are associated with healthy aging and exceptional survival. Oncotarget 6:3600-12
Stanko, Katie E; Cherry, Katie E; Ryker, Kyle S et al. (2015) Looking for the Silver Lining: Benefit Finding after Hurricanes Katrina and Rita in Middle-Aged, Older, and Oldest-Old Adults. Curr Psychol 34:564-575
Kim, Sangkyu; Jazwinski, S Michal (2015) Quantitative measures of healthy aging and biological age. Healthy Aging Res 4:

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