Core A will be responsible for the general organization of the program and for promoting productiveinteractions among all projects and cores and between this program and the scientific community. The corewill also promote, monitor, and report on the progress of the program. To achieve these goals, we proposethe following specific aims.
Aim 1 : Define the overall organization of the program and adjust its structureaccording to research developments and opportunities. The core leader has developed an interactiveprogram in disease-related neuroscience at the applicant institution, and the current proposal emergeddirectly from these research activities. The proposal also relates closely to the core leader's long-standingand fruitful collaboration with Dr. Masliah at UCSD, whose interests overlap widely with those of the othermembers of this program.
Aim 2 : Promote exchange among the projects and cores and monitor theirprogress toward the goals of the program. Research in this program will be carried out in five projects andfour cores. Core A will organize regular meetings of all program personnel to review and discuss progressand adjust experimental strategies as needed. We will continue to encourage and facilitate the developmentof web pages and databases to promote the exchange of information among program members.
Aim 3 :Ensure the efficient generation and safe storage of data, the timely preparation of progress reports, and thedissemination of research findings and materials. This will include instruction in safety procedures, backup ofelectronic files, and assistance with manuscript preparation, travel arrangements, and shipments ofmaterials.
Aim 4 : Arrange for external reviews of the research activities in the projects and cores and fosterthe acquisition of new approaches that could promote the progress of the program as a whole. The entireprogram will be reviewed annually by members of an external advisory board. Additional experts will beinvited to provide ad hoc input on specific components.
Aim 5 : Play an active role in the further developmentof UCSF's Mission Bay campus and help the project/core leaders take advantage of the many conceptualand technological advances that will emerge at this site. During the preceding funding period, we relocatedall three Gladstone Institutes, and with them most of this program, to the Mission Bay campus. Byconsolidating our laboratories, cores, and animal care facilities into the same research building located withinwalking distance from many UCSF colleagues with overlapping interests, this move further enhanced thestrength and potential of our program. Our new environment will greatly contribute to the success of theresearch proposed in this renewal application.
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