Abstract

The Biostatistics & Bioinformatics Core (Core 9004) will provide biostatistics, bioinformatics and data management support to subprojects 0001-0004, Core 9002 and Core 9003.
Specific aims of the Core 9004 are: (1) to provide data management support for Projects 0001-0004, Core 9002 and Core 9003; (2) to provide biostatistics and bioinformatics support to Core 9003 and microarray experiments proposed under Projects 0001, 0003 and 0004, and; (3) to provide biostatistical and mathematical modeling support to Projects 0001-0004.
Under Specific Aim #1, Core 9004 will develop a PPG web portal, data storage, data use policies including data sharing and publishing. The PPG web portal will streamline data entry, verification, storage, and retrieval across four projects and cores.
Under Specific Aim #2, Core 9004 will develop and implement a pre-processing and normalization protocol for Core 9003 as well as bioinformatics tools to efficiently retrieve and mine biological information from public databases. Further, Core 9004 will provide statistical analysis support for the microarray experiments and provide consultation on the design and analysis of the RT-PCR confirmation experiments.
Under Specific Aim #3, Core 9004 will provide data analysis support for all experiments proposed under Projects 0001-0004 and assist the investigators with data interpretation and manuscript preparation. Core 9004 will develop mathematical and statistical models if necessary and incorporate recently published methods such as the analysis of lymphocyte kinetics and turnover.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG023664-05
Application #
7675415
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2008-06-01
Budget End
2009-05-31
Support Year
5
Fiscal Year
2008
Total Cost
$142,453
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Type
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Hammarlund, Erika; Thomas, Archana; Amanna, Ian J et al. (2017) Plasma cell survival in the absence of B cell memory. Nat Commun 8:1781
Ouwendijk, Werner J D; van Veen, Suzanne; Mahalingam, Ravi et al. (2017) Simian varicella virus inhibits the interferon gamma signalling pathway. J Gen Virol :
Henderson, Heather H; Timberlake, Kensey B; Austin, Zoe A et al. (2016) Occupancy of RNA Polymerase II Phosphorylated on Serine 5 (RNAP S5P) and RNAP S2P on Varicella-Zoster Virus Genes 9, 51, and 66 Is Independent of Transcript Abundance and Polymerase Location within the Gene. J Virol 90:1231-43
Ouwendijk, Werner J D; Getu, Sarah; Mahalingam, Ravi et al. (2016) Characterization of the immune response in ganglia after primary simian varicella virus infection. J Neurovirol 22:376-88
Okoye, Afam A; Rohankhedkar, Mukta; Konfe, Audrie L et al. (2015) Effect of IL-7 Therapy on Naive and Memory T Cell Homeostasis in Aged Rhesus Macaques. J Immunol 195:4292-305
Verweij, Marieke C; Wellish, Mary; Whitmer, Travis et al. (2015) Varicella Viruses Inhibit Interferon-Stimulated JAK-STAT Signaling through Multiple Mechanisms. PLoS Pathog 11:e1004901
High, Kevin P; Akbar, Arne N; Nikolich-Zugich, Janko (2012) Translational research in immune senescence: assessing the relevance of current models. Semin Immunol 24:373-82
Cicin-Sain, Luka; Brien, James D; Uhrlaub, Jennifer L et al. (2012) Cytomegalovirus infection impairs immune responses and accentuates T-cell pool changes observed in mice with aging. PLoS Pathog 8:e1002849
Cicin-Sain, Luka; Sylwester, Andrew W; Hagen, Shoko I et al. (2011) Cytomegalovirus-specific T cell immunity is maintained in immunosenescent rhesus macaques. J Immunol 187:1722-32
Lang, Anna; Nikolich-Zugich, Janko (2011) Functional CD8 T cell memory responding to persistent latent infection is maintained for life. J Immunol 187:3759-68

Showing the most recent 10 out of 20 publications