The Physiology Core will provide integrated services to the researchers of the individual projects. The Core personnel will work to coordinate physiological testing of animals with each individual project directors. The auditory brainstem response will be the primary method to evaluate auditory sensitivity across all projects. The endocochlear potential will be measured to address the status of stria vascularis in young and old mice. The Physiology Core will also coordinate noise exposures of animals with respect to each investigator's needs for exposures that will produce either temporary (ITS) or permanent (PTS) threshold shifts to meet the needs of the projects. The Physiology Core will provide all of the standard materials and services to accomplish the physiological measurements. The results obtained from the procedures described in this core will be analyzed and coordinated for statistical significance with the Data Management team and they will serve as consultants to discuss interpretation of data and correlation with other results. The Core will analyze and prepare graphs for presentation at scientific forums and publication in scientific journals. To further promote efficient and successful Core operation, frequent meetings will be used to discuss progress in research, emerging techniques and assist in future directions. Procedures are in place for scheduling and prioritization of services and quality control. The Histology Core and Physiology Core will work closely together to coordinate physiological and morphological characterization of animals under experimental conditions.
| Altschuler, R A; Dolan, D F; Halsey, K et al. (2015) Age-related changes in auditory nerve-inner hair cell connections, hair cell numbers, auditory brain stem response and gap detection in UM-HET4 mice. Neuroscience 292:22-33 |
| Schacht, Jochen; Altschuler, Richard; Burke, David T et al. (2012) Alleles that modulate late life hearing in genetically heterogeneous mice. Neurobiol Aging 33:1842.e15-29 |
| Gong, Tzy-Wen; Fairfield, Damon A; Fullarton, Lynne et al. (2012) Induction of heat shock proteins by hyperthermia and noise overstimulation in hsf1 -/- mice. J Assoc Res Otolaryngol 13:29-37 |
| Sha, Su-Hua; Kanicki, Ariane; Halsey, Karin et al. (2012) Antioxidant-enriched diet does not delay the progression of age-related hearing loss. Neurobiol Aging 33:1010.e15-6 |
| Miller, Richard A; Dolan, David; Han, Melissa et al. (2011) Resistance of skin fibroblasts to peroxide and UV damage predicts hearing loss in aging mice. Aging Cell 10:362-3 |
| Leiser, Scott F; Miller, Richard A (2010) Nrf2 signaling, a mechanism for cellular stress resistance in long-lived mice. Mol Cell Biol 30:871-84 |
| Sha, Su-Hua; Chen, Fu-Quan; Schacht, Jochen (2010) PTEN attenuates PIP3/Akt signaling in the cochlea of the aging CBA/J mouse. Hear Res 264:86-92 |
| Sha, Su-Hua; Chen, Fu-Quan; Schacht, Jochen (2009) Activation of cell death pathways in the inner ear of the aging CBA/J mouse. Hear Res 254:92-9 |
| Sha, Su-Hua; Kanicki, Ariane; Dootz, Gary et al. (2008) Age-related auditory pathology in the CBA/J mouse. Hear Res 243:87-94 |
| Jiang, Hongyan; Talaska, Andra E; Schacht, Jochen et al. (2007) Oxidative imbalance in the aging inner ear. Neurobiol Aging 28:1605-12 |
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