The Animal Resources Core, to be led by Mollie Bloomsmith, PhD, will ensure that all animals selected forthe Program Project meet the entrance criteria developed jointly by the Program Project investigators. Inaddition, members of the Core will monitor the status of the subjects throughout the grant period to ensuretheir continued appropriateness. The nonhuman primate subjects will be obtained from the YNPRC colonywhich maintains a valuable resource of rhesus macaques and chimpanzees of appropriate age classes forthis research. Veterinary care will be supplied to promote health of the subjects and to manage theexperimental procedures included in the Program Project. Environmental enrichment, socialization, andanimal training programs will be applied to promote the psychological well-being of the nonhuman primatesubjects in these studies, and to facilitate the conduct of high quality research with this important population.
The specific aims of the Animal Resources Core are to: (1) Review the health and experimental records ofall animal subjects prior to assignment, to determine if they meet the selection criteria described below, (2)review the health status of all monkeys and chimpanzees in the Program Project on a regular basis, performroutine clinical examinations including blood analyses and ophthalmologic examinations, and insure that thecontinued use of individual animals by the Program Project is appropriate, (3) coordinate the assignment ofmonkeys and chimpanzees to specific research projects, so as to avoid scheduling conflicts between usersin the Program Project, (4) promote the psychological well-being of all monkeys and chimpanzees in theProgram Project by providing'environmental enrichment to minimize behavioral problems, coordinate thesocialization of subjects with their research use, and train animals to cooperate with experimentalprocedures using positive reinforcement techniques, (5) review results of postmortem autopsies andpathological surveys to determine whether undiagnosed health problems were present, the nature of whichwould warrant exclusion from the data analyses, (6) ensure prompt, thorough, and efficient access to allveterinary and animal-history records required by members of the Program Project, and, (7) ensureadequate oversight of anesthesia and documentation of recovery for designated experimental procedures.
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| Martin, Allison L; Franklin, Andrea N; Perlman, Jaine E et al. (2018) Systematic assessment of food item preference and reinforcer effectiveness: Enhancements in training laboratory-housed rhesus macaques. Behav Processes 157:445-452 |
| Donahue, Chad J; Glasser, Matthew F; Preuss, Todd M et al. (2018) Quantitative assessment of prefrontal cortex in humans relative to nonhuman primates. Proc Natl Acad Sci U S A 115:E5183-E5192 |
| Mars, Rogier B; Sotiropoulos, Stamatios N; Passingham, Richard E et al. (2018) Whole brain comparative anatomy using connectivity blueprints. Elife 7: |
| Lacreuse, Agnès; Parr, Lisa; Chennareddi, Lakshmi et al. (2018) Age-related decline in cognitive flexibility in female chimpanzees. Neurobiol Aging 72:83-88 |
| Hecht, E E; Mahovetz, L M; Preuss, T M et al. (2017) A neuroanatomical predictor of mirror self-recognition in chimpanzees. Soc Cogn Affect Neurosci 12:37-48 |
| Bruner, Emiliano; Preuss, Todd M; Chen, Xu et al. (2017) Evidence for expansion of the precuneus in human evolution. Brain Struct Funct 222:1053-1060 |
| Pereira-Pedro, Ana Sofia; Rilling, James K; Chen, Xu et al. (2017) Midsagittal Brain Variation among Non-Human Primates: Insights into Evolutionary Expansion of the Human Precuneus. Brain Behav Evol 90:255-263 |
| Donahue, Chad J; Sotiropoulos, Stamatios N; Jbabdi, Saad et al. (2016) Using Diffusion Tractography to Predict Cortical Connection Strength and Distance: A Quantitative Comparison with Tracers in the Monkey. J Neurosci 36:6758-70 |
| Rosen, Rebecca F; Tomidokoro, Yasushi; Farberg, Aaron S et al. (2016) Comparative pathobiology of ?-amyloid and the unique susceptibility of humans to Alzheimer's disease. Neurobiol Aging 44:185-196 |
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