Abstract

The Animal Resources Core (Core A) will provide young and middle age Sprague-Dawley rats of defined ovarian status used by all projects. Daily vaginal cytology will identify middle-aged irregular cyclers as a perimenopausal model. Some animals will be OVX and given replacements of estradiol (E2) with or without progesterone (P4). Necropsy will identify gross organ pathology, e.g. pituitary tumors. All projects also use the Alzheimer disease (AD) triple transgenic Alzheimer mouse: females of different ages will be OVXs and given steroid replacements. Tissues will be collected and deposited into storage managed by the Analytic Core. Blood will be given to the Analytic Core to be assayed for E2 and P4. A main goal of the animal core is the development of the rodent perimenopause and menopause model. These latter animal models will be crucial in determining the impact of reproductive aging on the neural responses to hormone therapy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG026572-04
Application #
7864196
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2009-06-01
Budget End
2010-05-31
Support Year
4
Fiscal Year
2009
Total Cost
$352,076
Indirect Cost

  Institution

Name
University of Southern California
Department
Type
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Geifman, Nophar; Kennedy, Richard E; Schneider, Lon S et al. (2018) Data-driven identification of endophenotypes of Alzheimer's disease progression: implications for clinical trials and therapeutic interventions. Alzheimers Res Ther 10:4
Walters, Michelle J; Sterling, Joanna; Quinn, Crystal et al. (2018) Associations of lifestyle and vascular risk factors with Alzheimer's brain biomarker changes during middle age: a 3-year longitudinal study in the broader New York City area. BMJ Open 8:e023664
Mosconi, Lisa; Brinton, Roberta Diaz (2018) How would we combat menopause as an Alzheimer's risk factor? Expert Rev Neurother 18:689-691
Mosconi, Lisa; Walters, Michelle; Sterling, Joanna et al. (2018) Lifestyle and vascular risk effects on MRI-based biomarkers of Alzheimer's disease: a cross-sectional study of middle-aged adults from the broader New York City area. BMJ Open 8:e019362
Moser, V Alexandra; Uchoa, Mariana F; Pike, Christian J (2018) TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity. J Neuroinflammation 15:306
Berkowitz, C L; Mosconi, L; Rahman, A et al. (2018) Clinical Application of APOE in Alzheimer's Prevention: A Precision Medicine Approach. J Prev Alzheimers Dis 5:245-252
Gahm, Jin Kyu; Shi, Yonggang; Alzheimer’s Disease Neuroimaging Initiative (2018) Riemannian metric optimization on surfaces (RMOS) for intrinsic brain mapping in the Laplace-Beltrami embedding space. Med Image Anal 46:189-201
Riedel, Brandalyn C; Daianu, Madelaine; Ver Steeg, Greg et al. (2018) Uncovering Biologically Coherent Peripheral Signatures of Health and Risk for Alzheimer's Disease in the Aging Brain. Front Aging Neurosci 10:390
Scheyer, O; Rahman, A; Hristov, H et al. (2018) Female Sex and Alzheimer's Risk: The Menopause Connection. J Prev Alzheimers Dis 5:225-230
Mosconi, Lisa; Berti, Valentina; Quinn, Crystal et al. (2017) Sex differences in Alzheimer risk: Brain imaging of endocrine vs chronologic aging. Neurology 89:1382-1390

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