Is it true that males are healthier than females but die younger? If so, why? We plan demographic analyses to address these two overarching questions concerning the health-survival paradox. First, to what extent is the paradox true? How general is it? * According to which definitions and measures and along which dimensions are men healthier than women? * How do male-female morbidity and mortality differences vary with age? * How do they vary over place? * How have they varied over time? * How do they vary across species of mammals, birds, reptiles, amphibians and fish? Second, to the extent that the paradox is true, why is this the case? Various social and biological hypotheses will be tested by analyzing: Human and nonhuman lifetables (Project 1); Survey and register data on humans in Denmark (Project 2); Survey data on humans in the United States (Project 3) and in Japan, the Philippines and Singapore (Project 4); Longitudinal observations on baboons in the wild in Kenya (Project 5); Longitudinal data on lemurs in the wild on Madagascar and in captivity at Duke and in France (Project 6);and Laboratory data on fruit flies (Project 7). The combination of informative animal models and high-quality human data and sophisticated demographic analyses will provide a deeper understanding of the basis for sex differences in health and survival and of opportunities to reduce these differences.

Public Health Relevance

Is it true that males are healthier than females but die younger? If so, why? This program project supports research projects that address these questions concerning the human health-survival paradox. Findings will provide a deeper understanding of the basis for sex differences in health and survival-and of the opportunities that society and particularly health professionals have to improve health and survival for males and females. REVIEW OF INDIVIDUAL COMPONENETS CORE A - ADMINISTRATION AND COORDINATION;Dr James Vaupel (CL) DESCRIPTION (provided by applicant): The Administrative Core is the nexus for coordination among the projects, including management of personnel and budgets, as well as organization of meetings and workshops and dissemination of research to share methodological and theoretical developments and empirical findings. The Administrative Core is charged with both internal and external liaison and integration. It coordinates interaction among the program's research projects and between the program and other research on aging. It is responsible for administrative coordination with the NIA/NIH and with the various universities and research centers associated with the program.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
1P01AG031719-01A1
Application #
7630124
Study Section
Special Emphasis Panel (ZAG1-ZIJ-7 (J2))
Program Officer
Haaga, John G
Project Start
2009-09-30
Project End
2014-08-31
Budget Start
2009-09-30
Budget End
2010-08-31
Support Year
1
Fiscal Year
2009
Total Cost
$849,791
Indirect Cost
Name
Duke University
Department
Miscellaneous
Type
Schools of Arts and Sciences
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Alberts, Susan C (2018) Social influences on survival and reproduction: Insights from a long-term study of wild baboons. J Anim Ecol :
Oksuzyan, Anna; Sauer, Torsten; Gampe, Jutta et al. (2018) Is Who you Ask Important? Concordance Between Survey and Registry Data on Medication Use Among Self- and Proxy-Respondents in the Longitudinal Study of Aging Danish Twins and the Danish 1905-Cohort Study. J Gerontol A Biol Sci Med Sci :
Gesquiere, Laurence R; Altmann, Jeanne; Archie, Elizabeth A et al. (2018) Interbirth intervals in wild baboons: Environmental predictors and hormonal correlates. Am J Phys Anthropol 166:107-126
Zarulli, Virginia; Barthold Jones, Julia A; Oksuzyan, Anna et al. (2018) Women live longer than men even during severe famines and epidemics. Proc Natl Acad Sci U S A 115:E832-E840
Oksuzyan, Anna; Singh, Prashant Kumar; Christensen, Kaare et al. (2018) A Cross-National Study of the Gender Gap in Health Among Older Adults in India and China: Similarities and Disparities. Gerontologist 58:1156-1165
Zeng, Yi; Nie, Chao; Min, Junxia et al. (2018) Sex Differences in Genetic Associations With Longevity. JAMA Netw Open 1:
Zhao, Xin; Liu, Xiaomin; Zhang, Aiping et al. (2018) The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese. Aging (Albany NY) 10:1206-1222
Gesquiere, Laurence R; Pugh, Mya; Alberts, Susan C et al. (2018) Estimation of energetic condition in wild baboons using fecal thyroid hormone determination. Gen Comp Endocrinol 260:9-17
Höhn, Andreas; Larsen, Lisbeth Aagaard; Schneider, Daniel Christoph et al. (2018) Sex differences in the 1-year risk of dying following all-cause and cause-specific hospital admission after age 50 in comparison with a general and non-hospitalised population: a register-based cohort study of the Danish population. BMJ Open 8:e021813
Santacroce, Adriana; Wastesson, Jonas W; Höhn, Andreas et al. (2018) Gender differences in the use of anti-infective medications before and after widowhood: a register-based study. J Epidemiol Community Health 72:526-531

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