Abstract

The three projects of our PPG examine male-female health-survival paradox by comparing numerous life tables, social, behavioral and other environmental factors in various human and nonhuman populations, but none of them deal with the effects of genetic variants and GxE interactions. As reviewer recommended ?Down the road, results from genetic demography will likely become important to the study of differential health and mortality by sex (P.10, PPG summary statement), This competing revision project focusing on sex differences in the effects of genetics & GxE interaction on cognition (emphasizing prevention of Alzheimer disease), mental health and survival would make significant contributions to expand our PPG and the research field.

Public Health Relevance

The PPG?s overall component of this competing revision project focusing on sex differences in the effects of genetics & GxE interaction on cognition (emphasizing prevention of Alzheimer disease), mental health and survival would make significant contributions to expand our PPG and the research field. We aim to contribute to future health promotion programs considering male and female individual differences in genetic characteristics, in order to increase the efficiency of the interventions. Our expanded PPG with this competing revision project is highly relevant to public health.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
3P01AG031719-07S1
Application #
9417837
Study Section
Neuroscience of Aging Review Committee (NIA)
Program Officer
Patmios, Georgeanne E
Project Start
2009-09-30
Project End
2021-04-30
Budget Start
2018-04-01
Budget End
2018-04-30
Support Year
7
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Duke University
Department
Miscellaneous
Type
Schools of Arts and Sciences
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Oksuzyan, Anna; Singh, Prashant Kumar; Christensen, Kaare et al. (2018) A Cross-National Study of the Gender Gap in Health Among Older Adults in India and China: Similarities and Disparities. Gerontologist 58:1156-1165
Zeng, Yi; Nie, Chao; Min, Junxia et al. (2018) Sex Differences in Genetic Associations With Longevity. JAMA Netw Open 1:
Zhao, Xin; Liu, Xiaomin; Zhang, Aiping et al. (2018) The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese. Aging (Albany NY) 10:1206-1222
Gesquiere, Laurence R; Pugh, Mya; Alberts, Susan C et al. (2018) Estimation of energetic condition in wild baboons using fecal thyroid hormone determination. Gen Comp Endocrinol 260:9-17
Höhn, Andreas; Larsen, Lisbeth Aagaard; Schneider, Daniel Christoph et al. (2018) Sex differences in the 1-year risk of dying following all-cause and cause-specific hospital admission after age 50 in comparison with a general and non-hospitalised population: a register-based cohort study of the Danish population. BMJ Open 8:e021813
Santacroce, Adriana; Wastesson, Jonas W; Höhn, Andreas et al. (2018) Gender differences in the use of anti-infective medications before and after widowhood: a register-based study. J Epidemiol Community Health 72:526-531
Alberts, Susan C (2018) Social influences on survival and reproduction: Insights from a long-term study of wild baboons. J Anim Ecol :
Oksuzyan, Anna; Sauer, Torsten; Gampe, Jutta et al. (2018) Is Who you Ask Important? Concordance Between Survey and Registry Data on Medication Use Among Self- and Proxy-Respondents in the Longitudinal Study of Aging Danish Twins and the Danish 1905-Cohort Study. J Gerontol A Biol Sci Med Sci :
Gesquiere, Laurence R; Altmann, Jeanne; Archie, Elizabeth A et al. (2018) Interbirth intervals in wild baboons: Environmental predictors and hormonal correlates. Am J Phys Anthropol 166:107-126
Zarulli, Virginia; Barthold Jones, Julia A; Oksuzyan, Anna et al. (2018) Women live longer than men even during severe famines and epidemics. Proc Natl Acad Sci U S A 115:E832-E840

Showing the most recent 10 out of 130 publications