Abstract

This competing revision Project focus on investigating the sex difference in effects of genetics & GxE interactions on elderly cognition, mental health and survival. Analyses will be based primarily on genotype/phenotype data from the Chinese Longitudinal Healthy Longevity Surveys (CLHLS), with replications and comparisons using available datasets from U.S. Health and Retirement Survey (HRS) and Singapore Han Chinese Health Study (SCHS).
We aim to contribute to future health promotion programs considering male and female individual differences in genetic characteristics, in order to increase the efficiency of the interventions.
The Aims of our interdisciplinary research are: (1) Identify sex-specific genetic variants significantly associated with cognition, mental health and survival at old ages, using CLHLS data. (2) Investigate sex differences in the effects of genetic variants identified in Aim (1) and GxE interactions on cognition, mental health and survival at old ages, using the CLHLS data. (3) International replicative/comparative analyses of genetic and GxE effects on cognition, mental health and longevity at old ages. We will use available GWAS and survey datasets from HRS and SCHS to replicate/compare the significant findings based on the CLHLS data (Aims (1)-(2)), to understand cross country and ethnic similarities and differences. (4) Develop an integrated CLHLS genotype/phenotype database for healthy aging studies which will represent the world?s largest samples of male and female centenarians, nonagenarians and other ages. The de-identified CLHLS genotypic/phenotypic data will be deposed in the NIH dbGaP program for other scholars? research.

Public Health Relevance

This competing revision project focuses on investigating ?Sex difference in effects of genetics & GxE interactions on elderly cognition, mental health and survival?, based on analyzing genotype/phenotype data from the Chinese Longitudinal Healthy Longevity Surveys (CLHLS), as well as replicative and comparative analyses across Chinese, Whites and African Americans using the CLHLS, U.S. Health and Retirement Survey and Singapore Chinese Health Survey datasets. We aim to contribute to future health promotion programs considering male and female individual differences in genetic characteristics, in order to increase the efficiency of the interventions. Our expanded PPG with this competing revision project is highly relevant to public health.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG031719-10
Application #
9922229
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2020-05-01
Budget End
2021-04-30
Support Year
10
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Zhao, Xin; Liu, Xiaomin; Zhang, Aiping et al. (2018) The correlation of copy number variations with longevity in a genome-wide association study of Han Chinese. Aging (Albany NY) 10:1206-1222
Gesquiere, Laurence R; Pugh, Mya; Alberts, Susan C et al. (2018) Estimation of energetic condition in wild baboons using fecal thyroid hormone determination. Gen Comp Endocrinol 260:9-17
Höhn, Andreas; Larsen, Lisbeth Aagaard; Schneider, Daniel Christoph et al. (2018) Sex differences in the 1-year risk of dying following all-cause and cause-specific hospital admission after age 50 in comparison with a general and non-hospitalised population: a register-based cohort study of the Danish population. BMJ Open 8:e021813
Santacroce, Adriana; Wastesson, Jonas W; Höhn, Andreas et al. (2018) Gender differences in the use of anti-infective medications before and after widowhood: a register-based study. J Epidemiol Community Health 72:526-531
Alberts, Susan C (2018) Social influences on survival and reproduction: Insights from a long-term study of wild baboons. J Anim Ecol :
Oksuzyan, Anna; Sauer, Torsten; Gampe, Jutta et al. (2018) Is Who you Ask Important? Concordance Between Survey and Registry Data on Medication Use Among Self- and Proxy-Respondents in the Longitudinal Study of Aging Danish Twins and the Danish 1905-Cohort Study. J Gerontol A Biol Sci Med Sci :
Gesquiere, Laurence R; Altmann, Jeanne; Archie, Elizabeth A et al. (2018) Interbirth intervals in wild baboons: Environmental predictors and hormonal correlates. Am J Phys Anthropol 166:107-126
Zarulli, Virginia; Barthold Jones, Julia A; Oksuzyan, Anna et al. (2018) Women live longer than men even during severe famines and epidemics. Proc Natl Acad Sci U S A 115:E832-E840
Oksuzyan, Anna; Singh, Prashant Kumar; Christensen, Kaare et al. (2018) A Cross-National Study of the Gender Gap in Health Among Older Adults in India and China: Similarities and Disparities. Gerontologist 58:1156-1165
Zeng, Yi; Nie, Chao; Min, Junxia et al. (2018) Sex Differences in Genetic Associations With Longevity. JAMA Netw Open 1:

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